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Difference between revisions of "Stomach"
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→Familial gastric carcinoma
m (→General) |
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Review paper: PMID 16950858. | Review paper: PMID 16950858. | ||
== | ==Hereditary gastric cancer== | ||
Several syndrome are associated with gastric cancer:<ref>{{Cite journal | last1 = Sereno | first1 = M. | last2 = Aguayo | first2 = C. | last3 = Guillén Ponce | first3 = C. | last4 = Gómez-Raposo | first4 = C. | last5 = Zambrana | first5 = F. | last6 = Gómez-López | first6 = M. | last7 = Casado | first7 = E. | title = Gastric tumours in hereditary cancer syndromes: clinical features, molecular biology and strategies for prevention. | journal = Clin Transl Oncol | volume = 13 | issue = 9 | pages = 599-610 | month = Sep | year = 2011 | doi = | PMID = 21865131 }}</ref> | |||
{| class="wikitable sortable" | |||
! Disease | |||
! Gene | |||
! Histology | |||
! Other | |||
|- | |||
| Hereditary diffuse gastric cancer (HDGC) syndrome | |||
| CDH1 (E-cadherin)<ref>{{OMIM|192090}}</ref> | |||
| diffuse - more specifically [[signet ring cell carcinoma]] | |||
| most important; assoc. [[invasive lobular carcinoma]]<ref name=pmid9537325>{{Cite journal | last1 = Guilford | first1 = P. | last2 = Hopkins | first2 = J. | last3 = Harraway | first3 = J. | last4 = McLeod | first4 = M. | last5 = McLeod | first5 = N. | last6 = Harawira | first6 = P. | last7 = Taite | first7 = H. | last8 = Scoular | first8 = R. | last9 = Miller | first9 = A. | title = E-cadherin germline mutations in familial gastric cancer. | journal = Nature | volume = 392 | issue = 6674 | pages = 402-5 | month = Mar | year = 1998 | doi = 10.1038/32918 | PMID = 9537325 }}</ref> | |||
|- | |||
| [[Lynch syndrome]] | |||
| several | |||
| ? | |||
| colorectal carcinoma, endometrial carcinoma | |||
|- | |||
| [[Familial adenomatous polyposis]] | |||
| APC | |||
| ? | |||
| adenomatous polyps | |||
|- | |||
| [[Peutz-Jeghers syndrome]] | |||
| STK11 | |||
| ? | |||
| stomach hamartomas - not precursor | |||
|- | |||
| [[Li-Fraumeni syndrome]] | |||
| TP53 (p53) | |||
| ? | |||
| ? | |||
|- | |||
| Hereditary breast and ovarian cancer | |||
| BRCA1 | |||
| | |||
| | |||
|} | |||
==Gastric adenocarcinoma== | ==Gastric adenocarcinoma== | ||