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Difference between revisions of "Lymph node pathology"
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→Progressive transformation of germinal centers
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==Progressive transformation of germinal centers== | ==Progressive transformation of germinal centers== | ||
*Abbreviated as ''PTGC''. | |||
===General=== | ===General=== | ||
*Benign. | *Benign. | ||
*Classically in younger patients. | *Classically in younger patients. | ||
*Associated with [[Hodgkin's lymphoma]] | *Associated with nodular lymphocyte predominant [[Hodgkin's lymphoma]] (NLPHL); NLPHL found in up to 5% in a 7 year follow-up.<ref name=pmid12145465>{{cite journal |author=Verma A, Stock W, Norohna S, Shah R, Bradlow B, Platanias LC |title=Progressive transformation of germinal centers. Report of 2 cases and review of the literature |journal=Acta Haematol. |volume=108 |issue=1 |pages=33–8 |year=2002 |pmid=12145465 |doi= |url=}}</ref> | ||
Clinical: | |||
*Asymptomatic lymphadenopathy. | |||
===Microscopic=== | ===Microscopic=== | ||
Features: | Features: | ||
*Follicular hyperplasia (many follicles). | |||
*'''Focally''' large germinal centers with: | *'''Focally''' large germinal centers with: | ||
**Poorly demarcated germinal center (GC)/mantle zone interfaces (as GCs infiltrated by mantle zone lymphocytes) -- '''key feature'''.<ref name=pmid12145465/> | |||
**Expanded mantle zone. | **Expanded mantle zone. | ||
==Reactive follicular hyperplasia== | ==Reactive follicular hyperplasia== | ||