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Difference between revisions of "Thyroid gland"
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→Hashimoto thyroiditis
(→Graves disease: +Ab) |
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**Often genetic/part of a syndrome. | **Often genetic/part of a syndrome. | ||
====Clinical==== | |||
Serology:<ref name=pmid7813361>{{cite journal |author=Poropatich C, Marcus D, Oertel YC |title=Hashimoto's thyroiditis: fine-needle aspirations of 50 asymptomatic cases |journal=Diagn. Cytopathol. |volume=11 |issue=2 |pages=141–5 |year=1994 |pmid=7813361 |doi= |url=http://www3.interscience.wiley.com/journal/112701408/abstract?CRETRY=1&SRETRY=0}}</ref> | |||
*Antimicrosomal (antithyroid peroxidase) +ve. | *Antimicrosomal (antithyroid peroxidase) +ve. | ||
*Antithyroglobulin +ve. | *Antithyroglobulin +ve. | ||
*Increased risk of B-cell lymphoma. | |||
Associated pathology:<ref name=pmid7813361/> | |||
*Increased risk of B-cell lymphoma; these are classically:<ref name=pmid18018576 >{{Cite journal | last1 = Ohye | first1 = H. | last2 = Fukata | first2 = S. | last3 = Hirokawa | first3 = M. | title = [Malignant lymphoma of the thyroid]. | journal = Nihon Rinsho | volume = 65 | issue = 11 | pages = 2092-8 | month = Nov | year = 2007 | doi = | PMID = 18018576 }}</ref> | |||
**[[MALT lymphoma]]. | |||
**[[Diffuse large B cell lymphoma]] (DLBCL). | |||
===Microscopic=== | ===Microscopic=== | ||
| Line 287: | Line 292: | ||
*[[Lymphocytic thyroiditis]]. | *[[Lymphocytic thyroiditis]]. | ||
*[[Papillary thyroid carcinoma]]. | *[[Papillary thyroid carcinoma]]. | ||
*[[MALT lymphoma]]. | |||
*[[Diffuse large B cell lymphoma]]. | |||
===IHC=== | |||
*Panel to exclude lymphoma may be required, e.g. CD3, CD20, CD10, BCL6, BCL2, kappa, lambda. | |||
===Molecular=== | |||
*Occasionally done to exclude lymphoma - see ''[[MALT lymphoma]]'' and ''[[DLBCL]]''. | |||
==C-cell hyperplasia== | ==C-cell hyperplasia== | ||