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Difference between revisions of "Thyroid gland"
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→IHC: +molecular
(→Subtypes of papillary thyroid carcinoma: +another subtype, poor prognosis types) |
(→IHC: +molecular) |
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| Line 456: | Line 456: | ||
*TTF-1 (thyroid transcription factor-1) +ve. | *TTF-1 (thyroid transcription factor-1) +ve. | ||
*CD15 +ve. (???) | *CD15 +ve. (???) | ||
===Molecular=== | |||
*Currently not widely used in a diagnostic context. | |||
====Tabular summary==== | |||
Molecular changes in papillary thyroid carcinoma as per ''Adeniran et al'':<ref name=pmid16434896>{{Cite journal | last1 = Adeniran | first1 = AJ. | last2 = Zhu | first2 = Z. | last3 = Gandhi | first3 = M. | last4 = Steward | first4 = DL. | last5 = Fidler | first5 = JP. | last6 = Giordano | first6 = TJ. | last7 = Biddinger | first7 = PW. | last8 = Nikiforov | first8 = YE. | title = Correlation between genetic alterations and microscopic features, clinical manifestations, and prognostic characteristics of thyroid papillary carcinomas. | journal = Am J Surg Pathol | volume = 30 | issue = 2 | pages = 216-22 | month = Feb | year = 2006 | doi = | PMID = 16434896 }}</ref> | |||
{| class="wikitable sortable" | |||
! Molecular change | |||
! Frequency | |||
! Histology | |||
! Notes | |||
|- | |||
|BRAF point mutations | |||
| ~ 40% | |||
| [[papillary thyroid carcinoma tall cell variant|tall cell variant]] | |||
| poorer prognosis, older individuals | |||
|- | |||
|RET/PTC rearrangments | |||
| ~ 20% | |||
| papillary architecture, [[psammoma bodies]] | |||
| younger individuals | |||
|- | |||
|RAS point mutations | |||
| ~ 15% | |||
| exclusively [[papillary thyroid carcinoma follicular variant|follicular variant]] | |||
| - | |||
|} | |||
==Insular carcinoma== | ==Insular carcinoma== | ||