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Difference between revisions of "Thyroid gland"
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Sternberg, APBR
(Sternberg, APBR) |
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===Granulomatous thyoiditis=== | ===Granulomatous thyoiditis=== | ||
Features:<ref> | Features:<ref name=Ref_Sternberg4_559>{{Ref Sternberg4|559}}</ref> | ||
*AKA ''de Quervain disease''. | *AKA ''de Quervain disease''. | ||
*Women > men. | *Women > men. | ||
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===Diagnosis=== | ===Diagnosis=== | ||
*Histologically often not possible to separate from "nonspecific" thyroiditis.<ref> | *Histologically often not possible to separate from "nonspecific" thyroiditis.<ref name=Ref_Sternberg4_560>{{Ref Sternberg4|560}}</ref> | ||
*Nuclear clearing common - ergo may confuse with papillary carcinoma. | *Nuclear clearing common - ergo may confuse with papillary carcinoma. | ||
*Polymorphous lymphoplasmacytic infiltrate with germinal centres.<ref>APBR | *Polymorphous lymphoplasmacytic infiltrate with germinal centres.<ref name=Ref_APBR672>{{Ref APBR|672}}</ref> | ||
==Malignant neoplasm== | ==Malignant neoplasm== | ||
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Notes: | Notes: | ||
*Associated with radiation exposure.<ref> | *Associated with radiation exposure.<ref name=Ref_Sternberg4_564>{{Ref Sternberg4|564}}</ref> | ||
===Histology=== | ===Histology=== | ||
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**Circular, acellular, eosinophilic whorled bodies. | **Circular, acellular, eosinophilic whorled bodies. | ||
**Not necessary to make diagnosis. | **Not necessary to make diagnosis. | ||
**Arise from infarction & calcification of papilla tips.<ref> | **Arise from infarction & calcification of papilla tips.<ref name=Ref_Sternberg4_565>{{Ref Sternberg4|565}}</ref> | ||
Notes: | Notes: | ||
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*At low power look for cellular areas/loss of follicles. | *At low power look for cellular areas/loss of follicles. | ||
*Nuclear clearing seen in: | *Nuclear clearing seen in: | ||
**Hashimoto's and papillary thyroid carcinoma.<ref> | **Hashimoto's and papillary thyroid carcinoma.<ref name=Ref_Sternberg4_566>{{Ref Sternberg4|566}}</ref> | ||
**May be an artifact of fixation/processing. | **May be an artifact of fixation/processing. | ||
*Nuclear overlapping is easy to see at lower power-- should be the tip-off to look at high power for nuclear features. | *Nuclear overlapping is easy to see at lower power-- should be the tip-off to look at high power for nuclear features. | ||