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Difference between revisions of "Lymphoma"
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m (→Anaplastic large cell lymphoma: +molecular) |
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==Plasmacytoma== | ==Plasmacytoma== | ||
===General=== | ===General=== | ||
*[[AKA]] ''plasma cell | *[[AKA]] ''plasma cell myeloma''. | ||
*Malignancy derived from the plasma cells. | *Malignancy derived from the plasma cells. | ||
*Histologic component of ''multiple myeloma''; to diagnose multiple myeloma other (non-pathology) criteria are needed. | *Histologic component of ''multiple myeloma''; to diagnose multiple myeloma other (non-pathology) criteria are needed. | ||
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Features: | Features: | ||
*Large cells with eosinophilic cytoplasm. | *Large cells with eosinophilic cytoplasm. | ||
* | *Usually appear cohesive. | ||
*May be subcapsular. | *May be subcapsular. | ||
*Large multinucleated cell - "wreath cell" - '''key feature'''. | *Large multinucleated cell - "wreath cell" - '''key feature'''. | ||
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|- | |- | ||
| Anaplastic large cell lymphoma | | Anaplastic large cell lymphoma | ||
| | | large | ||
| | | deep & subcapsular sinuses of LN | ||
| | | eosinophilic cytoplasm, nucleoli, often cohesive, wreath cell (C-shaped nucleus) | ||
| CD30+/-, Alk+/- | | CD30+/-, Alk+/-, CD4+, CD3- | ||
| | | t(2,5)(p23;q35)<ref name=pmid8547653>{{cite journal |author=Lamant L, Meggetto F, al Saati T, ''et al.'' |title=High incidence of the t(2;5)(p23;q35) translocation in anaplastic large cell lymphoma and its lack of detection in Hodgkin's disease. Comparison of cytogenetic analysis, reverse transcriptase-polymerase chain reaction, and P-80 immunostaining |journal=Blood |volume=87 |issue=1 |pages=284–91 |year=1996 |month=January |pmid=8547653 |doi= |url=}}</ref> | ||
| clinical ? | | clinical ? | ||
| | | uncommon | ||
| | | carcinoma | ||
|- | |- | ||
| Extranodal NK / T cell lymphoma nasal type | | Extranodal NK / T cell lymphoma nasal type | ||