Difference between revisions of "Gestational trophoblastic disease"

Gestational trophoblastic disease (view source)

487 bytes added , 05:06, 21 April 2012

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 DDx:
-*[[Exaggerated placental site]].
+*[[Exaggerated placental site]] - EPS has near zero Ki-67.
-**EPS vs. PSTT: EPS has a low MIB1 (Ki-67).
+*[[Choriocarcinoma]] - choriocarcinoma biphasic.<ref>URL: [http://www.webpathology.com/image.asp?n=3&Case=588 http://www.webpathology.com/image.asp?n=3&Case=588]. Accessed on: 1 January 2012.</ref>
-*[[Choriocarcinoma]].
-**PSTT vs. choriocarcinoma: choriocarcinoma biphasic.<ref>URL: [http://www.webpathology.com/image.asp?n=3&Case=588 http://www.webpathology.com/image.asp?n=3&Case=588]. Accessed on: 1 January 2012.</ref>
 Images:
 *[http://www.webpathology.com/case.asp?case=588 Collection of PSTT images (webpathology.com)].
+===IHC===
+Features:<ref>{{Cite journal  | last1 = Shih | first1 = IM. | last2 = Kurman | first2 = RJ. | title = Ki-67 labeling index in the differential diagnosis of exaggerated placental site, placental site trophoblastic tumor, and choriocarcinoma: a double immunohistochemical staining technique using Ki-67 and Mel-CAM antibodies. | journal = Hum Pathol | volume = 29 | issue = 1 | pages = 27-33 | month = Jan | year = 1998 | doi =  | PMID = 9445130 }}</ref>
+*CD146 +ve.
+*p63 -ve.
+*Ki-67 ~14+/-7%.
+**Choriocarcinoma ~69+/-20%.
 ==Epithelioid trophoblastic tumour==