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Difference between revisions of "Small cell lymphomas"
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→Hairy cell leukemia: +IHC
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(→Hairy cell leukemia: +IHC) |
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===General=== | ===General=== | ||
*Name comes from appearance on blood smear - cell hairy. | *Name comes from appearance on blood smear - cell hairy. | ||
* | |||
Clinical:<ref>URL: [http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A34022 http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A34022]. Accessed on: 20 August 2010.</ref> | |||
*Pancytopenia. | |||
*Splenic enlargement. | |||
*No lymphadenopathy. | |||
*Good prognosis (with treatment), though (likely) not curable. | |||
===Microscopic=== | ===Microscopic=== | ||
Features:<ref>URL: [http://emedicine.medscape.com/article/200580-diagnosis http://emedicine.medscape.com/article/200580-diagnosis]. Accessed on: 18 August 2010.</ref> | Features:<ref>URL: [http://emedicine.medscape.com/article/200580-diagnosis http://emedicine.medscape.com/article/200580-diagnosis]. Accessed on: 18 August 2010.</ref> | ||
*Small cells with: | *Small cells (10-20 micrometers) with "Fried egg"-like appearance: | ||
**Clear cytoplasm and, | **Well-demarcated fuzzy cell borders, | ||
**Clear/whispy cytoplasm and, | |||
**Central round nucleus. | **Central round nucleus. | ||
***" | ***Peri-nuclear clearing ("water-clear rim"<ref>URL: [http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A34022 http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A34022]. Accessed on: 20 August 2010.</ref>) -- '''key feature'''. | ||
Images: | Images: | ||
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*[http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A34022&rendertype=figure&id=A34027 HCL - bone marrow (nlm.nih.gov)] from [http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A34022 Holland-Frei Cancer Medicine (nlm.nih.gov)]. | *[http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A34022&rendertype=figure&id=A34027 HCL - bone marrow (nlm.nih.gov)] from [http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A34022 Holland-Frei Cancer Medicine (nlm.nih.gov)]. | ||
*[http://commons.wikimedia.org/wiki/File:Hairy_cell_leukemia_-_very_high_mag.jpg HCL - very high mag. (WC)]. | *[http://commons.wikimedia.org/wiki/File:Hairy_cell_leukemia_-_very_high_mag.jpg HCL - very high mag. (WC)]. | ||
===IHC=== | |||
Features:<ref>URL: [http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A34022&rendertype=table&id=A34029 http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A34022&rendertype=table&id=A34029]. Accessed on: 20 August 2010.</ref> | |||
*CD20 +ve, CD25 +ve, CD103 +ve. | |||
*CD5 -ve. | |||
Flow cytometry: | |||
*CD19 +ve, CD11c +ve, FMC7 +ve. | |||
==B cell small lymphocytic lymphoma/chronic lymphocytic leukemia== | ==B cell small lymphocytic lymphoma/chronic lymphocytic leukemia== | ||