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Difference between revisions of "Breast cytopathology"
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===Cytology=== | ===Cytology=== | ||
Features: | |||
#Cellular size variation. | *Classic five:<ref>{{Ref FNAC|137}}</ref> | ||
#Nuclear size variation. | *#Cellular size variation. | ||
#*May be marked adjacent cells different by factor of 2. | *#Nuclear size variation. | ||
#*Typically ''not'' marked - often ~1.5. | *#*May be marked adjacent cells different by factor of 2. | ||
#Nucleoli. | *#*Typically ''not'' marked - often ~1.5. | ||
#*Should be in every cell. | *#Nucleoli. | ||
#*Multiple suggestive of malignant. | *#*Should be in every cell. | ||
#Irregular chromatin pattern. | *#*Multiple suggestive of malignant. | ||
#Lack of singular bipolar nuclei (in the background), '''key negative'''. | *#Irregular chromatin pattern. | ||
Other features: | *#Lack of singular bipolar nuclei (in the background), '''key negative'''. | ||
*3-D clusters - strong indicator. | *Other features: | ||
*Cytoplasmic vacuoles - considered a classic finding. | **3-D clusters - strong indicator. | ||
**Cytoplasmic vacuoles - considered a classic finding. | |||
Notes: | Notes: | ||
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**Exceptions are ''tubular carcinoma'' and ''colloid carcinoma''; these have cells found in clusters or tubules/glands.<ref name=Ref_APBR678>{{Ref APBR|678}}</ref> | **Exceptions are ''tubular carcinoma'' and ''colloid carcinoma''; these have cells found in clusters or tubules/glands.<ref name=Ref_APBR678>{{Ref APBR|678}}</ref> | ||
*Intracytoplasmic "lumens"/inclusions (think ''lobular carcinoma''). | *Intracytoplasmic "lumens"/inclusions (think ''lobular carcinoma''). | ||
DDx: | |||
*[[Breast cytopathology#Fibroadenoma|Fibroadenoma]]. | |||
Images: | Images: | ||