Difference between revisions of "Basics"

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→‎Classification of granuloma: formating, memory device
(→‎Classification of granuloma: formating, memory device)
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===Classification of granuloma===
===Classification of granuloma===
Broadly they can be divided (histologically) into:
====Histologic classification====
*Necrosing (also ''caseating'').
#Necrosing (also ''caseating'').
**More likely to be infectious.
#*More likely to be infectious.
**Examples: Tuberculosis.
#*Examples: Tuberculosis (TB).
*Non-necrosing.
#Non-necrosing.
**Less likely to be infectious.
#*Less likely to be infectious.
**Examples: Crohn's disease, sarcoidosis, drug reaction.
#*Examples: Crohn's disease, sarcoidosis, drug reaction.


Whether necrosis is present in a granuloma is affected by the immune function, e.g. a HIV/AIDS patient may have non-necrosing granulomata due to TB.
Whether necrosis is present in a granuloma is affected by the immune function, e.g. a HIV/AIDS patient may have non-necrosing granulomata due to TB.
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*Infectious non-necrosing infections: Mycobacterium avium complex (MAC), cryptococcus, immunosuppressed individual.<ref name=pmid17257125/>
*Infectious non-necrosing infections: Mycobacterium avium complex (MAC), cryptococcus, immunosuppressed individual.<ref name=pmid17257125/>


Etiologic classification of granulomas:
====Etiologic classification====
#Infectious, e.g. tuberculosis, MAC, fungal infection.
#Infectious, e.g. tuberculosis, MAC, fungal infection.
#Neoplastic, e.g. seminoma.
#Neoplastic, e.g. seminoma.
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#Drug reaction.
#Drug reaction.
#Idiopathic, e.g. sarcoidosis.
#Idiopathic, e.g. sarcoidosis.
Memory device: ''DNF AAII'' = drug reaction, neoplasm, foreign body, allergy, autoimmune, idiopathic infection.


===Lung granulomata===
===Lung granulomata===
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