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Difference between revisions of "Mesothelial cytopathology"
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An introduction to cytopathology is in the ''[[cytopathology]]'' article. | An introduction to cytopathology is in the ''[[cytopathology]]'' article. | ||
=Cavity fluids= | |||
===Basic types=== | ===Basic types=== | ||
*'''Wash''', e.g. ''peritoneal wash'': expect sheets of (benign squamous) cells. | *'''Wash''', e.g. ''peritoneal wash'': expect sheets of (benign squamous) cells. | ||
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**Adenocarcinoma not otherwise specified (NOS). | **Adenocarcinoma not otherwise specified (NOS). | ||
**[[Serous carcinoma]]. | **[[Serous carcinoma]]. | ||
**[[Lymphoma]]. | **[[Lymphoma]]. | ||
**[[Squamous carcinoma]] - rare. | |||
===Peritoneal cavity specific=== | ===Peritoneal cavity specific=== | ||
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*High NC ratio. | *High NC ratio. | ||
=Normal mesothelium= | |||
Features:<ref name=Ref_APBR674>{{Ref APBR|674}}</ref> | Features:<ref name=Ref_APBR674>{{Ref APBR|674}}</ref> | ||
*"Window" or "space" between attached cells (due to microvilli). | *"Window" or "space" between attached cells (due to microvilli). | ||
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*Large clusters of cells, e.g. 150+ micrometres. | *Large clusters of cells, e.g. 150+ micrometres. | ||
=Specific diagnoses= | |||
==Malignant mesothelioma== | ==Malignant mesothelioma== | ||
{{Main|Malignant mesothelioma}} | {{Main|Malignant mesothelioma}} | ||
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#*Multiple nucleoli. | #*Multiple nucleoli. | ||
#*Irregular nucleoli (strong). | #*Irregular nucleoli (strong). | ||
Notes: | |||
*Single cells/small clusters - suggestive of mesothelioma vs. serous carcinoma. (???) | |||
Images: | Images: | ||
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*[http://commons.wikimedia.org/wiki/File:Mesothelioma_cytology_2.jpg Mesothelioma - 2 (WC)]. | *[http://commons.wikimedia.org/wiki/File:Mesothelioma_cytology_2.jpg Mesothelioma - 2 (WC)]. | ||
Mesothelioma versus reactive mesothelium:<ref name=Ref_DCHH359-60>{{Ref DCHH|359-60}}</ref> | |||
{| class="wikitable" | {| class="wikitable" | ||
|- | |- | ||
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Note 1: | Note 1: | ||
*Best assessed on single cells. | *Best assessed on single cells. | ||
===IHC=== | |||
*Calretin +ve. | |||
*WT-1 +ve. | |||
*D2-40 +ve. | |||
*TTF-1 -ve. | |||
*CEA -ve. | |||
==Breast carcinoma in fluid== | ==Breast carcinoma in fluid== | ||
===Cytology=== | |||
Breast adenocarcinoma in fluid - features:<ref name=Ref_APBR675>{{Ref APBR|675}}</ref> | Breast adenocarcinoma in fluid - features:<ref name=Ref_APBR675>{{Ref APBR|675}}</ref> | ||
*Classically large morules (clusters of cells that are heaped/are "3-dimensional"), known as ''cannonballs'', with "community borders". | *Classically large morules (clusters of cells that are heaped/are "3-dimensional"), known as ''cannonballs'', with "community borders". | ||
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*GI. | *GI. | ||
==Colorectal adenocarcinoma | ==Colorectal adenocarcinoma== | ||
{{Main|Colorectal adenocarcinoma}} | |||
*May be abbreviated ''CRA''. | |||
===General=== | |||
*Cytology may be distinctive. | |||
===Cytology=== | |||
Features: | Features: | ||
*Cannonballs (non-specific). | *Cannonballs (non-specific). | ||
| Line 189: | Line 201: | ||
*D2-40 +ve. | *D2-40 +ve. | ||
=See also= | |||
*[[Cytopathology]]. | *[[Cytopathology]]. | ||
*[[Urine cytopathology]]. | *[[Urine cytopathology]]. | ||
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*[[Urothelium]]. | *[[Urothelium]]. | ||
=References= | |||
{{reflist|2}} | {{reflist|2}} | ||
=External links= | |||
*[http://www.histopathology-india.net/MesoCyto.htm Mesothelioma (histopathology-india.net)]. | *[http://www.histopathology-india.net/MesoCyto.htm Mesothelioma (histopathology-india.net)]. | ||
*[http://www.cytology-asc.com/cec/respiratory/respneopl.htm Respiratory cytopathology (Australian Society)]. | *[http://www.cytology-asc.com/cec/respiratory/respneopl.htm Respiratory cytopathology (Australian Society)]. | ||
[[Category:Cytopathology]] | [[Category:Cytopathology]] | ||