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Difference between revisions of "Small cell lymphomas"
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→Small lymphocytic lymphoma/chronic lymphocytic leukemia: expand
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==Small lymphocytic lymphoma/chronic lymphocytic leukemia== | ==Small lymphocytic lymphoma/chronic lymphocytic leukemia== | ||
===General=== | ===General=== | ||
*Abbreviated ''CLL'' and ''SLL''. | |||
*Very common. | *Very common. | ||
*Good prognosis. | *Good prognosis. | ||
===Richter's transformation=== | |||
*CLL/SLL may under go a ''Richter's transformation'' into a high-grade non-Hodgkin's lymphoma (NHL), e.g. [[DLBCL]]:<ref name=pmid16616072>{{cite journal |author=Tsimberidou AM, Keating MJ |title=Richter's transformation in chronic lymphocytic leukemia |journal=Semin. Oncol. |volume=33 |issue=2 |pages=250–6 |year=2006 |month=April |pmid=16616072 |doi=10.1053/j.seminoncol.2006.01.016 |url=}}</ref> | |||
**Incidence of transformation <5%. | |||
**Prognosis < 1 year. | |||
===Microscopic=== | ===Microscopic=== | ||
Features: | Features in a lymph node:<ref>DG. 17 August 2010.</ref> | ||
* | *Mixed population of lymphoid cells with "proliferation centers" - '''key feature''': | ||
*#Larger cells (~ 1.5x the size of resting lymphocyte ~ 12-15 micrometers): | |||
*#*Nucleoli. | |||
*#*Form (nodular) collections. | |||
*#Small dark cells (~ size of resting lymphocyte ~ 8-10 micrometers): | |||
*#*Predominant population. | |||
*#*Lack nucleolus. | |||
Images: | |||
*[http://www.pathologyatlas.ro/chronic-lymphoid-leukemia-liver.php CLL in the liver (pathologyatlas.ro)]. | |||
==See also== | ==See also== | ||