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Difference between revisions of "Lymphoma"
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→Table of B-cell lymphoma: update
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(→Table of B-cell lymphoma: update) |
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*CD45 +ve. (???) | *CD45 +ve. (???) | ||
==Table of | ==Table of lymphoma== | ||
Lymphomas: | |||
{| class="wikitable" | {| class="wikitable sortable" style="margin-left:auto;margin-right:auto" | ||
! Name | ! Name | ||
! Size of cells | ! Size of cells | ||
! Site | |||
! Histomorphology | |||
! IHC | ! IHC | ||
! Translocations | ! Translocations | ||
! Clinical | ! Clinical | ||
! | ! Prevalence | ||
! DDx | |||
|- | |- | ||
| Follicular lymphoma | | Follicular lymphoma | ||
| | | small (centrocytes) | ||
| | | lymph node, germinal center | ||
| abundant atypical follicles (lack GC polarity, lack polar mantle zone), effaced sinuses, scattered large cells (centroblasts) | |||
| CD10+, bcl-6+<ref name=Ref_Lester95>{{Ref Lester|95}}</ref> | | CD10+, bcl-6+<ref name=Ref_Lester95>{{Ref Lester|95}}</ref> | ||
| t(14,18) | | t(14,18) | ||
| | | usually indolent, may transform to DLBCL | ||
| | | very common | ||
| DLBCL, other small cell lymphomas | |||
|- | |- | ||
| Mantle cell lymphoma | | Mantle cell lymphoma | ||
| | | small, monomorphic | ||
| | | lymph node, mantle zone | ||
| monomorphic lymphoid, abundant mitoses. +/-scattered epithelioid histiocytes, sclerosed blood vessels | |||
| CD5+, CD23-, CD43+, cyclin D1+<ref name=Ref_Lester95>{{Ref Lester|95}}</ref> | | CD5+, CD23-, CD43+, cyclin D1+<ref name=Ref_Lester95>{{Ref Lester|95}}</ref> | ||
| t(11;14)(q13;q32)<ref>URL: [http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html]. Accessed on: 10 August 2010.</ref> | | t(11;14)(q13;q32)<ref>URL: [http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html]. Accessed on: 10 August 2010.</ref> | ||
| | | indolent ??? | ||
| | | uncommon | ||
| other small cell lymphomas, PTGC, Castleman disease, Burkitt's lymphoma | |||
|- | |- | ||
| | | Extranodal marginal zone lymphoma (MALT lymphoma) | ||
| | | small | ||
| | | mucosa-associated lymphoid tissue, GI tract + elsewhere | ||
| +/- lymphepithelial lesion (cluster of 3+ cells in epithelium) | |||
| CD21+, CD11c+, CD5-, CD23-<ref name=Ref_Lester95>{{Ref Lester|95}}</ref> | | CD21+, CD11c+, CD5-, CD23-<ref name=Ref_Lester95>{{Ref Lester|95}}</ref> | ||
| | | ??? | ||
| | | indolent ??? | ||
| | | common | ||
| other small cell lymphomas, neuroendocrine tumours | |||
|- | |- | ||
| Precursor lymphoblastic lymphoma/leukemia | | Precursor lymphoblastic lymphoma/ leukemia | ||
| | | small | ||
| | | lymph node ??? | ||
| ??? | |||
| CD10+, CD5-, TdT+, CD99+<ref name=Ref_Lester95>{{Ref Lester|95}}</ref> | | CD10+, CD5-, TdT+, CD99+<ref name=Ref_Lester95>{{Ref Lester|95}}</ref> | ||
| | | translocations ??? | ||
| | | aggressive ??? | ||
| | | uncommon | ||
| | | small cell lymphomas | ||
|- | |- | ||
| Burkitt's lymphoma | | Burkitt's lymphoma | ||
| | | medium, monomorphic | ||
| | | lymph node, germinal center (???) | ||
| CD10, | | tingible-body macrophages ("starry sky" appearance), round nucleus, small nucleoli, mitoses +++ | ||
| CD10+, BCL6+, BCL2- | |||
| t(8;14) (q24;q32) | | t(8;14) (q24;q32) | ||
| | | rapid growth, may be associated with EBV, HIV/AIDS | ||
| | | uncommon | ||
| DLBCL, mantle cell lymphoma | |||
|- | |- | ||
| Diffuse large B cell lymphoma | | Diffuse large B cell lymphoma | ||
| | | large cells (>2x RBC, often larger), variable size | ||
| | | lymph node usually, germinal center | ||
| sheets of large discohesive cells; if only nodular = follicular lymphoma | |||
| MIB-1 >40% | | MIB-1 >40% | ||
| none/like follicular | | none / like follicular lymphoma t(14,18) / c-MYC (like Burkitt lymphoma) | ||
| | | poor prognosis | ||
| | | common among lymphomas | ||
|- | | Burkitt lymphoma, ALCL, Hodgkin lymphoma | ||
|- <!-- | |||
| Name | | Name | ||
| | | size of cells ? | ||
| | | site ? | ||
| IHC | | histomorphology ? | ||
| | | IHC ? | ||
| | | translocations ? | ||
| | | clinical ? | ||
| prevalence ? | |||
| DDx ? --> | |||
|} | |} | ||