Difference between revisions of "Thyroid gland"

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687 bytes added ,  03:05, 3 April 2012
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*May be genetic (MEN IIa/b syndrome).
*May be genetic (MEN IIa/b syndrome).
*Arises from C cells (which produce calcitonin).
*Arises from C cells (which produce calcitonin).
Syndromic tumours - typically:<ref name=pmid21455198>{{Cite journal  | last1 = Nosé | first1 = V. | title = Familial thyroid cancer: a review. | journal = Mod Pathol | volume = 24 Suppl 2 | issue =  | pages = S19-33 | month = Apr | year = 2011 | doi = 10.1038/modpathol.2010.147 | PMID = 21455198 |URL = http://www.nature.com/modpathol/journal/v24/n2s/full/modpathol2010147a.html }}</ref>
*Present in 30s or 40s.
*+/-Multifocal.
*+/-Bilateral.
*C-cell hyperplasia.
===Gross===
Features:<ref name=pmid21455198/>
*Usu. well-circumscribed.
*White, gray or yellow.
*Gritty.
*Firm.
Image:
*[http://www.nature.com/modpathol/journal/v24/n2s/fig_tab/modpathol2010147f2.html MTC (nature.com)].


===Microscopic===
===Microscopic===
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**Coarse chromatin (''salt and pepper nuclei'').
**Coarse chromatin (''salt and pepper nuclei'').
*+/-[[Amyloid]] deposits - fluffy appearing acellular eosinophilic material in the cytoplasm.
*+/-[[Amyloid]] deposits - fluffy appearing acellular eosinophilic material in the cytoplasm.
*C-cell hyperplasia (associated with familial forms of MTC).
**+/-C-cell hyperplasia - seen with familial forms of MTC.
**C cells (AKA ''parafollicular cell''): abundant cytoplasm - clear/pale.
**C cells (AKA ''parafollicular cell''): abundant cytoplasm - clear/pale.


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