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Difference between revisions of "Haematopathology"
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→Hodgkin's lymphoma: update micro
(→Microscopic: fix ref) |
(→Hodgkin's lymphoma: update micro) |
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*Reed-Sternberg cell. | *Reed-Sternberg cell. | ||
**Large binucleated cell. | **Large binucleated cell. | ||
***May be multinucleated. | |||
***May have a horseshoe-like shape. | |||
**Macronucleolus - approximately the size of a RBC (~8 micrometers). | **Macronucleolus - approximately the size of a RBC (~8 micrometers). | ||
**Well-defined cell border. | **Well-defined cell border. | ||
Notes: | |||
*Large mononuclear cells are common (so called "mononuclear RSCs") but not diagnostic. | |||
Images (classic HL): | Images (classic HL): | ||
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#Mixed cellularity CHL - ~20-25% of CHL. | #Mixed cellularity CHL - ~20-25% of CHL. | ||
#*Like nodular sclerosis - but no fibrosis. | #*Like nodular sclerosis - but no fibrosis. | ||
#*May be associated with HIV infection.<ref name=pmid20138008>{{cite journal |author=Sissolak G, Sissolak D, Jacobs P |title=Human immunodeficiency and Hodgkin lymphoma |journal=Transfus. Apher. Sci. |volume=42 |issue=2 |pages=131–9 |year=2010 |month=April |pmid=20138008 |doi=10.1016/j.transci.2010.01.008 |url=}}</ref> | |||
#Lymphocyte-rich CHL - rare. | #Lymphocyte-rich CHL - rare. | ||
#*T lymphocytes only (no mix of cells). | #*T lymphocytes only (no mix of cells). | ||
#Lymphocyte-depleted CHL - rare. | #Lymphocyte-depleted CHL - rare. | ||
#* | #*May be associated with HIV infection.<ref name=pmid20138008/> | ||
Memory device: | Memory device: | ||
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====Nodular lymphocyte-predominant HL==== | ====Nodular lymphocyte-predominant HL==== | ||
Features (nodular lymphocyte-predominant Hodgkin's lymphoma): | Features (nodular lymphocyte-predominant Hodgkin's lymphoma): | ||
*''Lymphocytic & histiocytic'' cell (L&H cell)<ref name=pmid9499174> | *''Popcorn cell'' (previously known as ''Lymphocytic & histiocytic'' cell (L&H cell)<ref name=pmid9499174>{{cite journal |author=Küppers R, Rajewsky K, Braeuninger A, Hansmann ML |title=L&H cells in lymphocyte-predominant Hodgkin's disease |journal=N. Engl. J. Med. |volume=338 |issue=11 |pages=763–4; author reply 764–5 |year=1998 |month=March |pmid=9499174 |doi=10.1056/NEJM199803123381113 |url=}}</ref>) - variant of RSC: | ||
**Cells (relatively) small (compared to classic RSCs). | **Cells (relatively) small (compared to classic RSCs). | ||
**Lobulated nucleus - '''key feature'''. | **Lobulated nucleus - '''key feature'''. | ||
**Small nucleoli. | **Small nucleoli. | ||
*Subtle nodularity at low power (2.5x or 5x objective). | |||
Images (NLPHL): | |||
*[http://webpathology.com/image.asp?case=388&n=16 Popcorn cell (webpathology.com)]. | *[http://webpathology.com/image.asp?case=388&n=16 Popcorn cell (webpathology.com)]. | ||
*[http://commons.wikimedia.org/wiki/File:Popcorn_cell_in_nodular_lymphocyte_predominant_Hodgkin_lymphoma_-_very_high_mag_cropped.jpg Popcorn cell (WC)]. | |||
==Follicular lymphoma== | ==Follicular lymphoma== | ||