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Difference between revisions of "Small cell lymphomas"
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→MALT lymphoma/Marginal zone lymphoma
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*t(11;14)(q13;q32).<ref>URL: [http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html]. Accessed on: 10 August 2010.</ref> | *t(11;14)(q13;q32).<ref>URL: [http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html]. Accessed on: 10 August 2010.</ref> | ||
== | ==Marginal zone lymphoma== | ||
===General=== | ===General=== | ||
*Abbreviated as ''MZL''. | *Abbreviated as ''MZL''. | ||
===Classification=== | ===Classification=== | ||
*Comes in different flavours: | *Comes in three different flavours: | ||
**Extranodal marginal zone lymphoma. | **Extranodal marginal zone lymphoma (AKA ''MALT lymphoma'' = mucosa-associated lymphoid tissue lymphoma). | ||
**Splenic marginal zone lymphoma. | **Splenic marginal zone lymphoma. | ||
**Nodal marginal zone lymphoma (NMZL). | |||
===Microscopic=== | ===Microscopic=== | ||
Features: | Features: | ||
*"Lymphoepithelial lesion" - gastric crypts invaded by a monomorphous population of lymphocytes.<ref name=pmid1452124>{{Cite journal | last1 = Papadaki | first1 = L. | last2 = Wotherspoon | first2 = AC. | last3 = Isaacson | first3 = PG. | title = The lymphoepithelial lesion of gastric low-grade B-cell lymphoma of mucosa-associated lymphoid tissue (MALT): an ultrastructural study. | journal = Histopathology | volume = 21 | issue = 5 | pages = 415-21 | month = Nov | year = 1992 | doi = | PMID = 1452124 }}</ref> | *"Lymphoepithelial lesion" - gastric crypts invaded by a monomorphous population of lymphocytes.<ref name=pmid1452124>{{Cite journal | last1 = Papadaki | first1 = L. | last2 = Wotherspoon | first2 = AC. | last3 = Isaacson | first3 = PG. | title = The lymphoepithelial lesion of gastric low-grade B-cell lymphoma of mucosa-associated lymphoid tissue (MALT): an ultrastructural study. | journal = Histopathology | volume = 21 | issue = 5 | pages = 415-21 | month = Nov | year = 1992 | doi = | PMID = 1452124 }}</ref> | ||
**Features: | **Features: | ||
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**# Clearing around the lymphocyte cluster. | **# Clearing around the lymphocyte cluster. | ||
**Not specific for MALT lymphoma, i.e. may be seen in other types of lymphoma.<ref>DB. 6 August 2010.</ref> | **Not specific for MALT lymphoma, i.e. may be seen in other types of lymphoma.<ref>DB. 6 August 2010.</ref> | ||
Images: | |||
*[http://commons.wikimedia.org/wiki/File:Gastrointestinal_lymphoepithelial_lesion_-_very_high_mag.jpg Lymphoepithelial lesion - very high mag. (WC)]. | |||
*[http://commons.wikimedia.org/wiki/File:Gastrointestinal_lymphoepithelial_lesion_-_intermed_mag.jpg Lymphoepithelial lesion - intermed. mag. (WC)]. | |||
===IHC=== | |||
Features:<ref>{{Ref Lester|95}}</ref> | |||
*CD20 +ve. | |||
*BCL2 +ve. | |||
*CD21 +ve. | |||
*CD11c +ve (flow cytometry or laser scanning cytometry - only; not available for paraffin). | |||
*CD43 +ve/-ve. | |||
**Typically positive in ''[[mantle cell lymphoma]]. | |||
Others: | |||
*CD5 -ve. | |||
*CD10 -ve. | |||
*CD23 -ve. | |||
==Hairy cell leukemia== | ==Hairy cell leukemia== | ||