48,536
edits
Difference between revisions of "Malignant melanoma"
Jump to navigation
Jump to search
→General
(→General: +regression) |
|||
| Line 5: | Line 5: | ||
==General== | ==General== | ||
*Known as the great mimicker in pathology; it may look like many things. | *Known as the great mimicker in pathology; it may look like many things. | ||
Pathologic predictors for a poor prognosis: | |||
*Tumour thickness (Brewslow thickness) > 1 mm. | |||
*Mitotic rate >1/mm^2. | |||
*Ulceration. | |||
*Regression - >75% of tumour. | |||
*Tumour infiltrating lymphocytes. | |||
*Microsatellitosis - nest of tumour cells > 0.05 mm size, separated from primary tumour >=0.3 mm and <= 2 cm. | |||
*In transist metastasis. | |||
*[[Lymphovascular invasion]]. | |||
*Perineural invasion. | |||
===Clinical=== | ===Clinical=== | ||
*''ABCD'' = asymmetric, borders (irregular), colour (black), diameter (large). | *''ABCD'' = asymmetric, borders (irregular), colour (black), diameter (large). | ||
Serologic predictors of a poor prognosis: | |||
*Lactate dehydrogenase (LDH) > 200-225 U/L. | |||
*Alumin < 35 g/L. | |||
==Microscopic== | ==Microscopic== | ||