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Difference between revisions of "Ovarian tumours"
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→Mucinous tumours: re-work, subdivide
(→Serous carcinoma of the ovary: more) |
(→Mucinous tumours: re-work, subdivide) |
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#Simple serous epithelium - with cilia. | #Simple serous epithelium - with cilia. | ||
==Mucinous tumours== | ==Mucinous tumours - overview== | ||
==General== | |||
*Common. | |||
*Tumours may be heterogenous; benign appearing epithelium may be beside clearly malignant epithelium. | |||
*Good sampling of mucinous tumours, i.e. many blocks, is important to lessen the chance of undercalling them. | |||
===Subtypes=== | |||
#''Endocervical type''. | |||
#*Less likely to be malignant. | |||
#*More common than malignant type. | |||
#''Intestinal type''. | |||
#*More likely to be malignant. | |||
#*[[Goblet cell]]s. (???) | |||
#**One large clear apical vacuole. | |||
#*If it doesn't look like intestine to you... it probably isn't. | |||
#*May vaguely resemble colorectal adenocarcinoma (hyperchromatic, columnar nuclei, nuclear pleomorphism). | |||
#**Image: [http://www.ispub.com/xml/journals/ijgo/vol9n1/papillary-fig4.jpg] | |||
Comparison of mucosa: | |||
*Normal endocervical mucosa: [http://pathology.mc.duke.edu/research/Histo_course/endocx.jpg endocervical mucosa]. | |||
*Normal colonic mucosa: [http://cellbio.utmb.edu/microanatomy/epithelia/00004493.jpg colonic type mucosa]. | |||
===Classification=== | |||
*Benign. (Dx: mucinous cystadenoma ''or'' mucinous adenofibroma ''or'' mucinous cystadenofibroma) | |||
**Single layer of cells. | |||
*Borderline. (Dx: ''mucinous tumour of uncertain malignant potential'' or ''borderline mucinous tumour'') | |||
**Papillae. | |||
*Malignant. (Dx: mucinous adenocarcinoma) | |||
**Usually intestinal subtype. | |||
==Mucinous adenocarcinoma of the ovary== | |||
*[[AKA]] ''ovarian mucinous adenocarcinoma''. | |||
===General=== | |||
*Malignant. | |||
*May arise in [[endometriosis]].<ref name=Ref_PBoD1097>{{Ref PBoD |1097}}</ref> | *May arise in [[endometriosis]].<ref name=Ref_PBoD1097>{{Ref PBoD |1097}}</ref> | ||
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*Multiloculated. | *Multiloculated. | ||
*Sticky, gelatinous fluid (glycoprotein). | *Sticky, gelatinous fluid (glycoprotein). | ||
*+/-[[Necrosis]]. | |||
===Microscopic=== | ===Microscopic=== | ||
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*Tall [[columnar cell]]s in glands. | *Tall [[columnar cell]]s in glands. | ||
**Apical mucin. | **Apical mucin. | ||
**May vaguely resemble colorectal adenocarcinoma. | **May vaguely resemble [[colorectal adenocarcinoma]]. | ||
*Glands have mucin. | *Glands have mucin. | ||
*+/-Nuclear atypia. | *+/-Nuclear atypia. | ||
* | *No [[cilia]]. | ||
*+/-Necrosis. | |||
===Subtypes=== | ====Subtypes==== | ||
#''Endocervical type''. | #''Endocervical type''. | ||
#*Less likely to be malignant. | #*Less likely to be malignant. | ||
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Comparison of mucosa: | Comparison of mucosa: | ||
*Normal endocervical mucosa: [http://pathology.mc.duke.edu/research/Histo_course/endocx.jpg endocervical mucosa]. | *Normal endocervical mucosa: [http://pathology.mc.duke.edu/research/Histo_course/endocx.jpg endocervical mucosa]. | ||
*Normal colonic mucosa: [http://cellbio.utmb.edu/microanatomy/epithelia/00004493.jpg colonic type mucosa]. | *Normal colonic mucosa: [http://cellbio.utmb.edu/microanatomy/epithelia/00004493.jpg colonic type mucosa]. | ||
=== | ===IHC=== | ||
* | *CK7 +ve. | ||
* | *CK20 +ve. | ||
==Endometrioid carcinoma of the ovary== | ==Endometrioid carcinoma of the ovary== | ||