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Difference between revisions of "Histiocytoses"
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===IHC=== | ===IHC=== | ||
Langerin (CD207).<ref>URL: [http://www.ncbi.nlm.nih.gov/omim/604862 http://www.ncbi.nlm.nih.gov/omim/604862]. Accessed on: 2 February 2011.</ref> | Langerin (CD207).<ref>URL: [http://www.ncbi.nlm.nih.gov/omim/604862 http://www.ncbi.nlm.nih.gov/omim/604862]. Accessed on: 2 February 2011.</ref> | ||
==Erdheim-Chester disease== | |||
===General=== | |||
*Rare. | |||
===Gross=== | |||
Features: | |||
*Bone involvement - classic. | |||
*Usually multiple systems are involved. | |||
===Microscopic=== | |||
Features:<ref name=pmid15509691>{{Cite journal | last1 = Sheu | first1 = SY. | last2 = Wenzel | first2 = RR. | last3 = Kersting | first3 = C. | last4 = Merten | first4 = R. | last5 = Otterbach | first5 = F. | last6 = Schmid | first6 = KW. | title = Erdheim-Chester disease: case report with multisystemic manifestations including testes, thyroid, and lymph nodes, and a review of literature. | journal = J Clin Pathol | volume = 57 | issue = 11 | pages = 1225-8 | month = Nov | year = 2004 | doi = 10.1136/jcp.2004.018481 | PMID = 15509691 }}</ref> | |||
*Foamy histocytes. | |||
**Large cells with gray, bubbly cytoplasm. | |||
*+/-Touton giant cells - very distinctive - '''classic'''. | |||
**Nuclei around cell periphery. | |||
DDx: | |||
*[[Rosai-Dorfman disease]]. | |||
*[[Langerhans cell histiocytosis]]. | |||
Images: | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1770491/figure/f1/ ECD (nih.gov)]. | |||
===IHC=== | |||
Features:<ref name=pmid17405844>{{Cite journal | last1 = Haroche | first1 = J. | last2 = Amoura | first2 = Z. | last3 = Touraine | first3 = P. | last4 = Seilhean | first4 = D. | last5 = Graef | first5 = C. | last6 = Birmelé | first6 = B. | last7 = Wechsler | first7 = B. | last8 = Cluzel | first8 = P. | last9 = Grenier | first9 = PA. | title = Bilateral adrenal infiltration in Erdheim-Chester disease. Report of seven cases and literature review. | journal = J Clin Endocrinol Metab | volume = 92 | issue = 6 | pages = 2007-12 | month = Jun | year = 2007 | doi = 10.1210/jc.2006-2018 | PMID = 17405844 }} | |||
</ref> | |||
*CD68 +ve. | |||
*S100 -ve/+ve. | |||
*CD1a -ve. | |||
==See also== | ==See also== | ||