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Difference between revisions of "Vulva"
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→Differentiated vulvar intraepithelial neoplasia: tweak
| Line 60: | Line 60: | ||
Epidemiology: | Epidemiology: | ||
*Associated with [[lichen sclerosus]]. | *Associated with [[lichen sclerosus]]. | ||
* | *Seen in older women. | ||
Note: | |||
*'''Not''' associated with [[HPV]]. | |||
===Microscopic=== | ===Microscopic=== | ||
Features: | Features:<ref name=pmid21057461>{{Cite journal | last1 = van de Nieuwenhof | first1 = HP. | last2 = Bulten | first2 = J. | last3 = Hollema | first3 = H. | last4 = Dommerholt | first4 = RG. | last5 = Massuger | first5 = LF. | last6 = van der Zee | first6 = AG. | last7 = de Hullu | first7 = JA. | last8 = van Kempen | first8 = LC. | title = Differentiated vulvar intraepithelial neoplasia is often found in lesions, previously diagnosed as lichen sclerosus, which have progressed to vulvar squamous cell carcinoma. | journal = Mod Pathol | volume = 24 | issue = 2 | pages = 297-305 | month = Feb | year = 2011 | doi = 10.1038/modpathol.2010.192 | PMID = 21057461 }}</ref> | ||
* | *Thickening of the stratum spinosum (acanthosis). | ||
*Elongation of rete ridges with bridging/anastomoses between rete ridges. | |||
*Nuclear atypia - esp. basal layer. | |||
*Nuclei in stratum corneum (parakeratosis). | |||
*+/-Atypical mitoses. | |||
Notes: | Notes: | ||