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Difference between revisions of "Gestational trophoblastic disease"
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Gestational trophoblastic disease (view source)
Revision as of 23:26, 9 March 2012
, 23:26, 9 March 2012→Entities - intermediate trophoblast
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| [[Placental site trophoblastic tumour]] (PSTT) | | [[Placental site trophoblastic tumour]] (PSTT) | ||
| abundant cytoplasm - not clear | | abundant cytoplasm - not clear, dyscohesive | ||
| +/-multinucleation | | +/-multinucleation | ||
| MIB1 high | | MIB1 high, p63 -ve, CD146 +ve | ||
| [[EPS]] | | [[EPS]] | ||
| Other? | | Other? | ||
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| nests of cells in hyaline stroma | | nests of cells in hyaline stroma | ||
| eosinophilic cytoplasm, central nucleus | | eosinophilic cytoplasm, central nucleus | ||
| MIB1 low | | MIB1 low, p63 +ve, CD146 -ve | ||
| [[squamous carcinoma]] | | [[squamous carcinoma]] | ||
| Other? | | Other? | ||
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| polygonal cells with clear cytoplasm (cytotrophoblasts) | | polygonal cells with clear cytoplasm (cytotrophoblasts) | ||
| multinucleated cells with smudged nuclei (syncytiotrophoblasts), usu. '''no''' [[chorionic villi]] | | multinucleated cells with smudged nuclei (syncytiotrophoblasts), usu. '''no''' [[chorionic villi]] | ||
| beta-hCG | | beta-hCG +ve, p63 +ve | ||
| DDx? | | DDx? | ||
| elevated beta-hCG (serum); '''not''' intermediate trophoblast derived. | | elevated beta-hCG (serum); '''not''' intermediate trophoblast derived. | ||
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*Benign. | *Benign. | ||
*Intermediate trophoblast remnants from a previous gestation.<ref name=pmid19332926>{{Cite journal | last1 = Jacob | first1 = S. | last2 = Mohapatra | first2 = D. | title = Placental site nodule: a tumor-like trophoblastic lesion. | journal = Indian J Pathol Microbiol | volume = 52 | issue = 2 | pages = 240-1 | month = | year = | doi = | PMID = 19332926 | url = http://www.ijpmonline.org/text.asp?2009/52/2/240/48931 }}</ref> | *Intermediate trophoblast remnants from a previous gestation.<ref name=pmid19332926>{{Cite journal | last1 = Jacob | first1 = S. | last2 = Mohapatra | first2 = D. | title = Placental site nodule: a tumor-like trophoblastic lesion. | journal = Indian J Pathol Microbiol | volume = 52 | issue = 2 | pages = 240-1 | month = | year = | doi = | PMID = 19332926 | url = http://www.ijpmonline.org/text.asp?2009/52/2/240/48931 }}</ref> | ||
Clinical: | |||
*Vaginal bleed. | |||
===Microscopic=== | ===Microscopic=== | ||
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*Derived from ''intermediate trophoblast''. | *Derived from ''intermediate trophoblast''. | ||
*Follows pregnancy. | *Follows pregnancy. | ||
*May be associated with [[nephrotic syndrome]]<ref name=pmid15457847>{{Cite journal | last1 = Bonazzi | first1 = C. | last2 = Urso | first2 = M. | last3 = Dell'Anna | first3 = T. | last4 = Sacco | first4 = S. | last5 = Buda | first5 = A. | last6 = Cantú | first6 = MG. | title = Placental site trophoblastic tumor: an overview. | journal = J Reprod Med | volume = 49 | issue = 8 | pages = 585-8 | month = Aug | year = 2004 | doi = | PMID = 15457847 }}</ref> with granular IgM staining.<ref>{{Cite journal | last1 = Komatsuda | first1 = A. | last2 = Nakamoto | first2 = Y. | last3 = Asakura | first3 = K. | last4 = Yasuda | first4 = T. | last5 = Imai | first5 = H. | last6 = Miura | first6 = AB. | title = Case report: nephrotic syndrome associated with a total hydatidiform mole. | journal = Am J Med Sci | volume = 303 | issue = 5 | pages = 309-12 | month = May | year = 1992 | doi = | PMID = 1580319 }}</ref> | |||
Clinical: | Clinical: | ||