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==Lupus erythematosus== | ==Lupus erythematosus== | ||
===General=== | |||
{{Main|Systemic lupus erythematosus}} | {{Main|Systemic lupus erythematosus}} | ||
*Systemic disease with multi-organ manifestations. | *Systemic disease with multi-organ manifestations. | ||
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DDx: | DDx: | ||
*[[Discoid lupus]]. | *[[Discoid lupus erythematosus]]. | ||
*Drug reaction (drug-induced lupus erythematosus). | |||
Images: | Images: | ||
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**[http://commons.wikimedia.org/wiki/File:Vacuolar_interface_dermatitis_-_intermed_mag.jpg Vacuolar interface dermatitis with dermal mucin - intermed. mag. (WC)]. | **[http://commons.wikimedia.org/wiki/File:Vacuolar_interface_dermatitis_-_intermed_mag.jpg Vacuolar interface dermatitis with dermal mucin - intermed. mag. (WC)]. | ||
**[http://commons.wikimedia.org/wiki/File:Vacuolar_interface_dermatitis_-_high_mag.jpg Vacuolar interface dermatitis with dermal mucin - high mag. (WC)]. | **[http://commons.wikimedia.org/wiki/File:Vacuolar_interface_dermatitis_-_high_mag.jpg Vacuolar interface dermatitis with dermal mucin - high mag. (WC)]. | ||
==Discoid lupus erythematosus== | |||
===General=== | |||
*Typically self-limited and isolated. | |||
**It is '''not''' associated with ''[[systemic lupus erythematosus]]''. | |||
===Microscopic=== | |||
Features:<ref>URL: [http://www.dermpedia.org/baby-dermpedia-for-beginners/discoid-lupus-erythematosus http://www.dermpedia.org/baby-dermpedia-for-beginners/discoid-lupus-erythematosus]. Accessed on: 7 March 2012.</ref> | |||
*Lymphocytic interface dermatitis with basal layer vacuolation and keratinocyte apoptosis. | |||
*Deep dermal lymphocytes. | |||
*Basket weave stratum corneum. | |||
*Dermal mucin. | |||
*Thick dermal-epidermal basement membrane. | |||
DDx: | |||
*[[Lupus erythematosus]]. | |||
Image: | |||
*[http://www.dermpedia.org/baby-dermpedia-for-beginners/discoid-lupus-erythematosus DLE (dermpedia.org)]. | |||
==Dermatomyositis== | ==Dermatomyositis== |
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