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Difference between revisions of "Basics"
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→Signet ring cells: tweak
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See: ''[[Lymph node]]'' article for a detailed description of cell types in a lymph node. | See: ''[[Lymph node]]'' article for a detailed description of cell types in a lymph node. | ||
===Signet ring | ===Signet ring cell carcinoma=== | ||
{{Main|Signet ring cell carcinoma}} | |||
*It has been said that there are two types of pathologists... those that have missed SRCs ''and'' those that will miss SRCs. | |||
* | |||
Microscopic: | |||
* | *Cells resemble signet rings: | ||
**They contain a large amount of mucin, which pushes the nucleus to the cell periphery. | |||
**The pool of mucin in a signet ring cell mimics the appearance of a finger hole. | |||
**The nucleus mimics the appearance of the face of the ring in profile. | |||
*Cells typically 2-3x the size of a lymphocyte. | |||
**Smaller than the typical adipocyte. | **Smaller than the typical adipocyte. | ||
*Often have a | *Often have a crescent-shaped ''or'' ovoid nucleus. | ||
**Capillaries sectioned on their lumen have endothelial cells-- the nuclei of these are more spindled. | **Capillaries sectioned on their lumen have endothelial cells -- the nuclei of these are more spindled. | ||
*SRCs are usually close to friend | *SRCs are usually close to friend -- another SRC. | ||
**This helps differentiate SRCs from capillaries sectioned on their lumen. | **This helps differentiate SRCs from capillaries sectioned on their lumen. | ||
*The mucin is often clear on H&E... but maybe eosinophilic. | *The mucin is often clear on H&E... but maybe eosinophilic. | ||
DDx: | |||
*Fat atrophy. | |||
Stains: | Stains: | ||
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Images: | Images: | ||
*[http://www.engravingarts.com/sales/LVX2.jpg Signet rings (engravingarts.com)]. | |||
*[http://commons.wikimedia.org/wiki/File:Signet_ring_cells_5.jpg SRCs (H&E) by Nephron (WC)]. | *[http://commons.wikimedia.org/wiki/File:Signet_ring_cells_5.jpg SRCs (H&E) by Nephron (WC)]. | ||
*[http://commons.wikimedia.org/wiki/File:Gastric_signet_ring_cell_carcinoma_histopatholgy_(2)_PAS_stain.jpg SRC AL-PAS stain (WC)]. | *[http://commons.wikimedia.org/wiki/File:Gastric_signet_ring_cell_carcinoma_histopatholgy_(2)_PAS_stain.jpg SRC AL-PAS stain (WC)]. | ||
*[http://commons.wikimedia.org/wiki/File:Gastric_signet_ring_cell_carcinoma_histopatholgy_(1).jpg SRC H&E stain (WC)]. | *[http://commons.wikimedia.org/wiki/File:Gastric_signet_ring_cell_carcinoma_histopatholgy_(1).jpg SRC H&E stain (WC)]. | ||
===Necrosis=== | ===Necrosis=== | ||