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Difference between revisions of "Medical liver disease"
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→Primary biliary cirrhosis: more +florid duct lesion
m (→Microscopic) |
(→Primary biliary cirrhosis: more +florid duct lesion) |
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===General=== | ===General=== | ||
Epidemiology: | |||
*Female>male (~9:1).<ref>{{Ref DCHH|162}}</ref> | *Female>male (~9:1).<ref>{{Ref DCHH|162}}</ref> | ||
*Usually middle age. | *Usually middle age. | ||
*Associated with other autoimmune conditions ([[Sjoegren's syndrome]], progressive systemic sclerosis, [[celiac disease]]). | *Associated with other autoimmune conditions ([[Sjoegren's syndrome]], progressive systemic sclerosis, [[celiac disease]]). | ||
Etiology: | |||
*Autoimmune. | *Autoimmune. | ||
Serology: | |||
*AMA+. | *AMA+. | ||
Classic presentation: | |||
*Pruritis. | *Pruritis. | ||
Pathophysiology: | |||
*Septal bile duct attacked. | *Septal bile duct attacked. | ||
Treatment: | |||
*Ursodeoxycholic acid. | *Ursodeoxycholic acid. | ||
*May be indication for transplant. | *May be indication for transplant. | ||
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===Microscopic=== | ===Microscopic=== | ||
Features: | Features: | ||
*Intraepithelial lymphocytes - in bile duct - '''key feature'''. | *"Florid duct lesion":<ref name=pmid7905494>{{Cite journal | last1 = Nakanuma | first1 = Y. | last2 = Harada | first2 = K. | title = Florid duct lesion in primary biliary cirrhosis shows highly proliferative activities. | journal = J Hepatol | volume = 19 | issue = 2 | pages = 216-21 | month = Sep | year = 1993 | doi = | PMID = 7905494 }}</ref> | ||
*Bile duct epithelial cells with eosinophilic cytoplasm.<ref>OA. 11 September 2009.</ref> | **Intraepithelial lymphocytes - in bile duct - '''key feature'''. | ||
**Bile duct epithelial cells with eosinophilic cytoplasm.<ref>OA. 11 September 2009.</ref> | |||
*Plasma cells. | *Plasma cells. | ||
*[[Granulomas]] - close to bile duct. | *[[Granulomas]] - close to bile duct. | ||