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Difference between revisions of "Lymph node pathology"
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→Kikuchi disease: +SLE
m (→Micrograph) |
m (→Kikuchi disease: +SLE) |
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*Lymphocytes (CD8 +ve). | *Lymphocytes (CD8 +ve). | ||
*Plasmacytoid dendritic cells. | *Plasmacytoid dendritic cells. | ||
Notes: | Notes: | ||
| Line 194: | Line 193: | ||
**Long membrane projections - '''key feature'''. | **Long membrane projections - '''key feature'''. | ||
**Abundant blue-grey cytoplasm, +/- ground-glass appearance. | **Abundant blue-grey cytoplasm, +/- ground-glass appearance. | ||
**Nucleus: small, ovoid, usu. single | **Nucleus: small, ovoid, usu. single nucleolus. | ||
Images: | Images: | ||
| Line 206: | Line 205: | ||
*CD4, CD20, CD3, and CD30 - mixed. | *CD4, CD20, CD3, and CD30 - mixed. | ||
**Done to excluded lymphoma; should show a mixed population of lymphocytes. | **Done to excluded lymphoma; should show a mixed population of lymphocytes. | ||
==Systemic lupus erythematosus lymphadenopathy== | |||
===General=== | |||
*Lymphadenopathy associated with systemic lupus erythematosus (SLE). | |||
===Microscopic=== | |||
Features:<ref name=pmid9406250>{{Cite journal | last1 = Kojima | first1 = M. | last2 = Nakamura | first2 = S. | last3 = Itoh | first3 = H. | last4 = Yoshida | first4 = K. | last5 = Asano | first5 = S. | last6 = Yamane | first6 = N. | last7 = Komatsumoto | first7 = S. | last8 = Ban | first8 = S. | last9 = Joshita | first9 = T. | title = Systemic lupus erythematosus (SLE) lymphadenopathy presenting with histopathologic features of Castleman' disease: a clinicopathologic study of five cases. | journal = Pathol Res Pract | volume = 193 | issue = 8 | pages = 565-71 | month = | year = 1997 | doi = | PMID = 9406250 }}</ref> | |||
*Necrosis. | |||
*Hematoxylin bodies (in necrotic foci). | |||
**Dark blue irregular bodies on H&E. | |||
DDx: | |||
*Kikuchi disease. | |||
==Castleman disease== | ==Castleman disease== | ||