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Difference between revisions of "Testis"
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→Seminoma: more
(→Seminoma: mroe) |
(→Seminoma: more) |
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DDx: | DDx: | ||
*[[ | *[[Embryonal carcinoma]]. | ||
*Solid variant of [[yolk sac tumour]]. | *Solid variant of [[yolk sac tumour]]. | ||
**Lacks fibrous septae and lymphocytes.<ref>URL: [http://webpathology.com/image.asp?case=34&n=8 http://webpathology.com/image.asp?case=34&n=8]. Accessed on: March 8, 2010.</ref> | **Lacks fibrous septae and lymphocytes.<ref>URL: [http://webpathology.com/image.asp?case=34&n=8 http://webpathology.com/image.asp?case=34&n=8]. Accessed on: March 8, 2010.</ref> | ||
*[[Mixed germ cell tumour]]. | |||
*[[Choriocarcinoma]] - esp. if (multinucleated) syncytiotrophoblasts are present. | *[[Choriocarcinoma]] - esp. if (multinucleated) syncytiotrophoblasts are present. | ||
*Granulomatous orchitis - if [[granuloma]]s are present. | *Granulomatous orchitis - if [[granuloma]]s are present. | ||
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*D2-40 +ve. | *D2-40 +ve. | ||
*CD117 +ve (ckit). | *CD117 +ve (ckit). | ||
*CD30 -ve.<ref name=pmid16867864>PMID 16867864 | *CD30 -ve.<ref name=pmid16867864>{{Cite journal | last1 = Cossu-Rocca | first1 = P. | last2 = Jones | first2 = TD. | last3 = Roth | first3 = LM. | last4 = Eble | first4 = JN. | last5 = Zheng | first5 = W. | last6 = Karim | first6 = FW. | last7 = Cheng | first7 = L. | title = Cytokeratin and CD30 expression in dysgerminoma. | journal = Hum Pathol | volume = 37 | issue = 8 | pages = 1015-21 | month = Aug | year = 2006 | doi = 10.1016/j.humpath.2006.02.018 | PMID = 16867864 }}</ref> | ||
**Done to r/o embryonal carcinoma. | **Done to r/o [[embryonal carcinoma]]. | ||
*Cytokeratins usu. -ve, may have weak focal positivity.<ref name=pmid16867864/> | *Cytokeratins usu. -ve, may have weak focal positivity.<ref name=pmid16867864/> | ||
*OCT3/4 +ve.<ref name=pmid20438407>{{Cite journal | last1 = Emerson | first1 = RE. | last2 = Ulbright | first2 = TM. | title = Intratubular germ cell neoplasia of the testis and its associated cancers: the use of novel biomarkers. | journal = Pathology | volume = 42 | issue = 4 | pages = 344-55 | month = Jun | year = 2010 | doi = 10.3109/00313021003767355 | PMID = 20438407 }}</ref> | *OCT3/4 +ve.<ref name=pmid20438407>{{Cite journal | last1 = Emerson | first1 = RE. | last2 = Ulbright | first2 = TM. | title = Intratubular germ cell neoplasia of the testis and its associated cancers: the use of novel biomarkers. | journal = Pathology | volume = 42 | issue = 4 | pages = 344-55 | month = Jun | year = 2010 | doi = 10.3109/00313021003767355 | PMID = 20438407 }}</ref> | ||