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Difference between revisions of "Germ cell tumours"
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===Molecular pathology=== | |||
Most common cytogenetic abnormality in GCTs: | |||
*Isochromosome p12.<ref name=pmid10357096>{{Cite journal | last1 = Looijenga | first1 = LH. | last2 = Oosterhuis | first2 = JW. | title = Pathogenesis of testicular germ cell tumours. | journal = Rev Reprod | volume = 4 | issue = 2 | pages = 90-100 | month = May | year = 1999 | doi = | PMID = 10357096 }}</ref> | |||
**Isochromosome = one arm (p or q) is lost and replaced with a duplicate of the remaining one. | |||
***Example: isochromosome p12 = chromosome 12 where q is lost and two p arms are present.<ref>URL: [http://ghr.nlm.nih.gov/handbook/illustrations/isochromosomes http://ghr.nlm.nih.gov/handbook/illustrations/isochromosomes]. Accessed on: 15 February 2012.</ref> | |||
==Germinoma== | ==Germinoma== | ||