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Difference between revisions of "Haematopathology"
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→Microscopic: update from Hodgkin's lymphoma article
(→Microscopic: update from Hodgkin's lymphoma article) |
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By definition, HL has Reed-Sternberg cells (RSCs). | By definition, HL has Reed-Sternberg cells (RSCs). | ||
====Classical HL==== | |||
Features (classic HL): | Features (classic HL): | ||
*Reed-Sternberg cell. | *Reed-Sternberg cell. | ||
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*[http://en.wikipedia.org/wiki/File:Hodgkin_lymphoma_%281%29_mixed_cellulary_type.jpg HL mixed cellularity (WC)]. | *[http://en.wikipedia.org/wiki/File:Hodgkin_lymphoma_%281%29_mixed_cellulary_type.jpg HL mixed cellularity (WC)]. | ||
Features ( | =====Subtypes===== | ||
*Cells (relatively) small (compared to classic RSCs). | There are four CHL subtypes:<ref name=Ref_WMSP567/> | ||
*Lobulated nucleus - '''key feature'''. | #Nodular sclerosis CHL - ~70% of CHL. | ||
*Small nucleoli. | #*Mixed cellular background - T cell, plasma cells, eosinophils, neutrophils and histiocytes. | ||
#*Nodular sclerosing fibrosis - thick strands fibrosis. | |||
#Mixed cellularity CHL - ~20-25% of CHL. | |||
#*Like nodular sclerosis - but no fibrosis. | |||
#Lymphocyte-rich CHL - rare. | |||
#*T lymphocytes only (no mix of cells). | |||
#Lymphocyte-depleted CHL - rare. | |||
#*Assoc. with HIV infection. | |||
Memory device: | |||
*The subtypes prevalence is in reverse alphabetical order. | |||
====Nodular lymphocyte-predominant HL==== | |||
Features (nodular lymphocyte-predominant Hodgkin's lymphoma): | |||
*''Lymphocytic & histiocytic'' cell (L&H cell)<ref name=pmid9499174>PMID: 9499174</ref> - variant of RSC: | |||
**Cells (relatively) small (compared to classic RSCs). | |||
**Lobulated nucleus - '''key feature'''. | |||
**Small nucleoli. | |||
Image (NLPHL): | Image (NLPHL): | ||