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Difference between revisions of "Immunohistochemical staining"
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Immunohistochemical staining (view source)
Revision as of 18:49, 9 February 2012
, 18:49, 9 February 2012→Thyroid and lung: +thyroglobulin
m (→CK7+ CK20+: w) |
(→Thyroid and lung: +thyroglobulin) |
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**Very good for [[breast]] vs. [[lung]].<ref name=pmid18318581>{{cite journal |author=Jagirdar J |title=Application of immunohistochemistry to the diagnosis of primary and metastatic carcinoma to the lung |journal=Arch. Pathol. Lab. Med. |volume=132 |issue=3 |pages=384–96 |year=2008 |month=March |pmid=18318581 |doi= |url=http://journals.allenpress.com/jrnlserv/?request=get-abstract&issn=0003-9985&volume=132&page=384}}</ref> | **Very good for [[breast]] vs. [[lung]].<ref name=pmid18318581>{{cite journal |author=Jagirdar J |title=Application of immunohistochemistry to the diagnosis of primary and metastatic carcinoma to the lung |journal=Arch. Pathol. Lab. Med. |volume=132 |issue=3 |pages=384–96 |year=2008 |month=March |pmid=18318581 |doi= |url=http://journals.allenpress.com/jrnlserv/?request=get-abstract&issn=0003-9985&volume=132&page=384}}</ref> | ||
***Often negative in squamous cell carcinoma of the lung (as with CK7 & CK20), though HMWK is usually positive. | ***Often negative in squamous cell carcinoma of the lung (as with CK7 & CK20), though HMWK is usually positive. | ||
*Thyroglobulin usu. +ve in the thyroid.<ref>{{Cite journal | last1 = Dralle | first1 = H. | last2 = Böcker | first2 = W. | title = [Thyroglobulin immunohistochemistry: new aspects of pathophysiology and differential diagnosis of benign and malignant goitre (author's transl)]. | journal = Langenbecks Arch Chir | volume = 356 | issue = 3 | pages = 205-12 | month = | year = 1982 | doi = | PMID = 7070163 }}</ref> | |||
Image: [http://commons.wikimedia.org/wiki/File:Lung_adenocarcinoma_-_TTF-1_-_high_mag.jpg Adenocarcinoma with nuclear TTF-1 positivity (WC)]. | Image: [http://commons.wikimedia.org/wiki/File:Lung_adenocarcinoma_-_TTF-1_-_high_mag.jpg Adenocarcinoma with nuclear TTF-1 positivity (WC)]. | ||
===Breast markers=== | ===Breast markers=== | ||
*GCDFP-15 ([[AKA]] BRST-2) -- specific, but NOT sensitive. | *GCDFP-15 ([[AKA]] BRST-2) -- specific, but NOT sensitive. | ||