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Difference between revisions of "Breast cytopathology"
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APBR
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(APBR) |
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===Pitfalls=== | ===Pitfalls=== | ||
False negative: | False negative: | ||
*Lobular carcinoma - often single cells (may be in "chains"/"single file"), slightly hypercellular, cells appear bland/normal cytologically (if not carefully examined).<ref>APBR | *Lobular carcinoma - often single cells (may be in "chains"/"single file"), slightly hypercellular, cells appear bland/normal cytologically (if not carefully examined).<ref name=Ref_APBR678>{{Ref APBR|678}}</ref> | ||
===Malignancy - the short version=== | ===Malignancy - the short version=== | ||
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Notes: | Notes: | ||
*Typically single cells present.<ref>APBR | *Typically single cells present.<ref name=Ref_APBR678_Q16>{{Ref APBR|678 (Q16)}}</ref> | ||
**Exceptions are ''tubular carcinoma'' and ''colloid carcinoma''; these have cells found in clusters or tubules/glands.<ref>APBR | **Exceptions are ''tubular carcinoma'' and ''colloid carcinoma''; these have cells found in clusters or tubules/glands.<ref name=Ref_APBR678>{{Ref APBR|678}}</ref> | ||
*Intracytoplasmic "lumens"/inclusions (think ''lobular carcinoma''). | *Intracytoplasmic "lumens"/inclusions (think ''lobular carcinoma''). | ||
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==Fibroadenoma== | ==Fibroadenoma== | ||
Features:<ref>APBR | Features:<ref name=Ref_APBR676>{{Ref APBR|676}}</ref> | ||
*Flat sheet of cells with '''mixed population - key feature''': | *Flat sheet of cells with '''mixed population - key feature''': | ||
**Cells with round nuclei (epithelium). | **Cells with round nuclei (epithelium). | ||
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==Apocrine metaplasia/fibrocystic changes== | ==Apocrine metaplasia/fibrocystic changes== | ||
Features:<ref>APBR | Features:<ref name=Ref_APBR677>{{Ref APBR|677}}</ref> | ||
*Architecture - pretty much anything (flat, single, papillary, clusters, sheets). | *Architecture - pretty much anything (flat, single, papillary, clusters, sheets). | ||
*Oncocytic change: | *Oncocytic change: | ||
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==Paget's disease== | ==Paget's disease== | ||
Features:<ref>APBR | Features:<ref name=Ref_APBR677>{{Ref APBR|677}}</ref> | ||
*Usually large cells with: | *Usually large cells with: | ||
**Nuclear atypia and nucleolus. | **Nuclear atypia and nucleolus. | ||