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Difference between revisions of "Salivary glands"
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→Oncocytoma: more, chg the name
(fix refs.) |
(→Oncocytoma: more, chg the name) |
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**[http://path.upmc.edu/cases/case281.html Sebaceous lymphadenoma (upmc.edu)]. | **[http://path.upmc.edu/cases/case281.html Sebaceous lymphadenoma (upmc.edu)]. | ||
==Oncocytoma== | ==Oncocytoma of the salivary gland== | ||
===General=== | ===General=== | ||
*No risk of malignant transformation. | *No risk of malignant transformation. | ||
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*Typical age: 60s-80s. | *Typical age: 60s-80s. | ||
*Associated with radiation exposure. | *Associated with radiation exposure. | ||
*Major salivary glands - | *Major salivary glands - usually parotid gland.<ref name=pmid19796983>{{Cite journal | last1 = Zhou | first1 = CX. | last2 = Gao | first2 = Y. | title = Oncocytoma of the salivary glands: a clinicopathologic and immunohistochemical study. | journal = Oral Oncol | volume = 45 | issue = 12 | pages = e232-8 | month = Dec | year = 2009 | doi = 10.1016/j.oraloncology.2009.08.004 | PMID = 19796983 }}</ref> | ||
===Gross=== | ===Gross=== | ||
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***Due to increased number of mitochrondria. | ***Due to increased number of mitochrondria. | ||
**Fine capillaries. | **Fine capillaries. | ||
*Architecture: solid sheets, trabeculae or duct-like structure.<ref name=pmid19796983/> | |||
Notes: | Notes: | ||
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===IHC=== | ===IHC=== | ||
*p63 +ve focally in nucleus. | *p63 +ve<ref name=pmid20614263>{{Cite journal | last1 = McHugh | first1 = JB. | last2 = Hoschar | first2 = AP. | last3 = Dvorakova | first3 = M. | last4 = Parwani | first4 = AV. | last5 = Barnes | first5 = EL. | last6 = Seethala | first6 = RR. | title = p63 immunohistochemistry differentiates salivary gland oncocytoma and oncocytic carcinoma from metastatic renal cell carcinoma. | journal = Head Neck Pathol | volume = 1 | issue = 2 | pages = 123-31 | month = Dec | year = 2007 | doi = 10.1007/s12105-007-0031-4 | PMID = 20614263 }}</ref> focally in nucleus. | ||
=Malignant= | =Malignant= | ||