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Difference between revisions of "Heart valves"
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→Calcific aortic stenosis: +amyloidosis of the valve
(→Calcific aortic stenosis: +symptoms) |
(→Calcific aortic stenosis: +amyloidosis of the valve) |
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| Line 88: | Line 88: | ||
**It affects the fibrosa. | **It affects the fibrosa. | ||
*Primarily at the base of the valve, i.e. there is relative sparing the free edge. | *Primarily at the base of the valve, i.e. there is relative sparing the free edge. | ||
==Amyloidosis of heart valves== | |||
===General=== | |||
*Common:<ref name=pmid6190729>{{Cite journal | last1 = Cooper | first1 = JH. | title = Localized dystrophic amyloidosis of heart valves. | journal = Hum Pathol | volume = 14 | issue = 7 | pages = 649-53 | month = Jul | year = 1983 | doi = | PMID = 6190729 }}</ref> | |||
**~80% of valves with calcific degeneration, i.e. [[calcific aortic stenosis]]. | |||
**~50% of valves with post-rheumatic sclerosis. | |||
*Not seen in acute disease, healed endocarditis.<ref name=pmid6190729/> | |||
===Microscopic=== | |||
Features: | |||
*Pink amorphous material - '''key feature'''. | |||
**Commonly around the calicific foci.<ref name=pmid6190729/> | |||
===Stains=== | |||
*Congo red +ve. | |||
Dystrophic amyloid:<ref name=pmid6190729/> | |||
*Alcian blue -ve. | |||
*Periodic acid-Schiff -ve. | |||
==Myxomatous degeneration== | ==Myxomatous degeneration== | ||