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Difference between revisions of "Lymphoma"
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→Angioimmunoblastic T-cell lymphoma: more
| Line 334: | Line 334: | ||
Features: | Features: | ||
*Intermediate size cells with: | *Intermediate size cells with: | ||
** | **+/-Vesicular nuclei. | ||
** | **Clear, moderate cytoplasm. | ||
*"Empty" sinus; subcapsular sinuses "open". | *"Empty" sinus; subcapsular sinuses "open". | ||
Images: | Images: | ||
*[http://www.ijpmonline.org/viewimage.asp?img=IndianJPatholMicrobiol_2010_53_4_640_72010_f4.jpg AITL (ijpmonline.org)].<ref name=pmid21045384>{{Cite journal | last1 = Bal | first1 = M. | last2 = Gujral | first2 = S. | last3 = Gandhi | first3 = J. | last4 = Shet | first4 = T. | last5 = Epari | first5 = S. | last6 = Subramanian | first6 = PG. | title = Angioimmunoblastic T-Cell lymphoma: a critical analysis of clinical, morphologic and immunophenotypic features. | journal = Indian J Pathol Microbiol | volume = 53 | issue = 4 | pages = 640-5 | month = | year = | doi = 10.4103/0377-4929.72010 | PMID = 21045384 | URL = http://www.ijpmonline.org/text.asp?2010/53/4/640/72010 }}</ref> | |||
*[http://path.upmc.edu/cases/case650.html AITL - several images (upmc.edu)] | *[http://path.upmc.edu/cases/case650.html AITL - several images (upmc.edu)] | ||
===IHC=== | ===IHC=== | ||
Features - positives:<ref name=pmid21045384/> | |||
*CD3 +ve. | |||
*CD5 +ve. | |||
*CD43 +ve. | |||
Others: | |||
*CD4 +ve and CD8 +ve with CD4>CD8. | *CD4 +ve and CD8 +ve with CD4>CD8. | ||
*CD20 +ve/-ve! | |||
*CD10 +ve/-ve! | |||
*CD21 +ve -- prominent FDC meshworks;<ref>URL: [http://path.upmc.edu/cases/case650/dx.html http://path.upmc.edu/cases/case650/dx.html]. Accessed on: 27 January 2012.</ref> tumour cell not +ve. | |||
Negatives: | |||
*CD30 -ve.<ref name=pmid21045384/> | |||
*CD15 -ve.<ref name=pmid21045384/> | |||
*CD7 -ve. | *CD7 -ve. | ||
*TIA-1 -ve. | *TIA-1 -ve. | ||
==Primary mediastinal B-cell lymphoma== | ==Primary mediastinal B-cell lymphoma== | ||