Difference between revisions of "Neuropathology"

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Neuropathology (view source)

Revision as of 12:06, 27 January 2012

No change in size ,  12:06, 27 January 2012
mv NMO to weird stuff
(→‎Multiple sclerosis: +Neuromyelitis optica)
(mv NMO to weird stuff)
Line 579: Line 579:
*HAM-56 - macrophages.
*HAM-56 - macrophages.
*CD8 - lymphocytes.
*CD8 - lymphocytes.
==Neuromyelitis optica==
*Abbreviated ''NMO''.
===General===
*Rare autoimmune disease - once considered a variant of [[multiple sclerosis]].
**Autoantibodies directed at aquaporin-4.<ref name=pmid22087205>{{Cite journal  | last1 = Kim | first1 = W. | last2 = Kim | first2 = SH. | last3 = Kim | first3 = HJ. | title = New insights into neuromyelitis optica. | journal = J Clin Neurol | volume = 7 | issue = 3 | pages = 115-27 | month = Sep | year = 2011 | doi = 10.3988/jcn.2011.7.3.115 | PMID = 22087205 }}</ref>
Diagnosis:
*NMO-IgG.
Clinical - preferentially:
*Eye (optic neuritis).
*Spinal cord (myelitis).
===Microscopic===
Features:
*Inflammation - lymphocytes, macrophages.
*Reactive astrocytes.
Images:
*[http://path.upmc.edu/cases/case637.html Neuromyelitis optica - several images (upmc.edu)].
===IHC===
*Mixed lymphocyte population with CD3 > CD20.
*Aquaporin-4 loss.


==Cerebral amyloid angiopathy==
==Cerebral amyloid angiopathy==
Line 716: Line 691:
*Acute necrotizing hemorrhagic encephalomyelitis (ANHE) - if one considers this a separate entity.
*Acute necrotizing hemorrhagic encephalomyelitis (ANHE) - if one considers this a separate entity.
*Acute necrotizing encephalopathy.<ref>URL: [http://path.upmc.edu/cases/case619/dx.html http://path.upmc.edu/cases/case619/dx.html]. Accessed on: 26 January 2012.</ref>
*Acute necrotizing encephalopathy.<ref>URL: [http://path.upmc.edu/cases/case619/dx.html http://path.upmc.edu/cases/case619/dx.html]. Accessed on: 26 January 2012.</ref>
==Neuromyelitis optica==
*Abbreviated ''NMO''.
===General===
*Rare autoimmune disease - once considered a variant of [[multiple sclerosis]].
**Autoantibodies directed at aquaporin-4.<ref name=pmid22087205>{{Cite journal  | last1 = Kim | first1 = W. | last2 = Kim | first2 = SH. | last3 = Kim | first3 = HJ. | title = New insights into neuromyelitis optica. | journal = J Clin Neurol | volume = 7 | issue = 3 | pages = 115-27 | month = Sep | year = 2011 | doi = 10.3988/jcn.2011.7.3.115 | PMID = 22087205 }}</ref>
Diagnosis:
*NMO-IgG.
Clinical - preferentially:
*Eye (optic neuritis).
*Spinal cord (myelitis).
===Microscopic===
Features:
*Inflammation - lymphocytes, macrophages.
*Reactive astrocytes.
Images:
*[http://path.upmc.edu/cases/case637.html Neuromyelitis optica - several images (upmc.edu)].
===IHC===
*Mixed lymphocyte population with CD3 > CD20.
*Aquaporin-4 loss.


==Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy==
==Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy==
Michael
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