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#Alcohol = alcoholic steatohepatitis (ASH). | #Alcohol = alcoholic steatohepatitis (ASH). | ||
#Not alcohol = non-alcoholic steatohepatitis (NASH). | #Not alcohol = non-alcoholic steatohepatitis (NASH). | ||
Notes: | Notes: | ||
*Pathologists can comment on the etiology; however, the histomorphology is not distinctive. In other words, ''ASH'' and ''NASH'' are clinical diagnoses. | *Pathologists can comment on the etiology; however, the histomorphology is not distinctive. In other words, ''ASH'' and ''NASH'' are clinical diagnoses. | ||
*''Steatohepatitis'' is a misnomer. It is '''not''' an ''-itis''; inflammation is '''not''' the (predominant) pathologic process. | |||
===Microscopic=== | ===Microscopic=== | ||
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**Late-stage disease - portal bridging.<ref name=pmid14991537>{{Cite journal | last1 = Gramlich | first1 = T. | last2 = Kleiner | first2 = DE. | last3 = McCullough | first3 = AJ. | last4 = Matteoni | first4 = CA. | last5 = Boparai | first5 = N. | last6 = Younossi | first6 = ZM. | title = Pathologic features associated with fibrosis in nonalcoholic fatty liver disease. | journal = Hum Pathol | volume = 35 | issue = 2 | pages = 196-9 | month = Feb | year = 2004 | doi = | PMID = 14991537 }}</ref> | **Late-stage disease - portal bridging.<ref name=pmid14991537>{{Cite journal | last1 = Gramlich | first1 = T. | last2 = Kleiner | first2 = DE. | last3 = McCullough | first3 = AJ. | last4 = Matteoni | first4 = CA. | last5 = Boparai | first5 = N. | last6 = Younossi | first6 = ZM. | title = Pathologic features associated with fibrosis in nonalcoholic fatty liver disease. | journal = Hum Pathol | volume = 35 | issue = 2 | pages = 196-9 | month = Feb | year = 2004 | doi = | PMID = 14991537 }}</ref> | ||
Image: [http://commons.wikimedia.org/wiki/File:Steatohepatitis_high_mag.jpg Steatohepatitis (WC)]. | |||
DDx: | |||
*[[Wilson disease]]. | |||
*[[Hepatitis C]]. | |||
*[[Drug reaction]]. | |||
===Grading steatohepatitis=== | ===Grading steatohepatitis=== |
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