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(→Alpha-1 antitrypsin deficiency: tweak) |
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===Microscopic=== | ===Microscopic=== | ||
Features: | Features: | ||
*Pink globules in zone 1. | *Pink globules in zone 1 (periportal). | ||
**Globules ''not'' seen in children. | **Globules ''not'' seen in children. | ||
**May ''not'' be present in late stage (cirrhotic). | **May ''not'' be present in late stage (cirrhotic). | ||
**Best seen on [[ | **Best seen on [[PASD stain]]. | ||
**Can be seen on H&E -- if one looks carefully. | **Can be seen on H&E -- if one looks carefully. | ||
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===IHC=== | ===IHC=== | ||
* | *A1-AT globules +ve.<Ref name=pmid3512609>{{Cite journal | last1 = Theaker | first1 = JM. | last2 = Fleming | first2 = KA. | title = Alpha-1-antitrypsin and the liver: a routine immunohistological screen. | journal = J Clin Pathol | volume = 39 | issue = 1 | pages = 58-62 | month = Jan | year = 1986 | doi = | PMID = 3512609 }}</ref> | ||
=Other= | =Other= |
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