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==Location and cell types== | ==Location and cell types== | ||
Germinal centers:<ref>Wheater's FH. 4th Ed. P.210.</ref> | Germinal centers:<ref>Wheater's FH. 4th Ed. P.210.</ref> | ||
*Site of B lymphocyte proliferation; ''follicle center cells''. | *Site of B lymphocyte proliferation; ''follicle center cells''. | ||
** | **Centroblasts - usually superficial aspect. | ||
***Darker, larger, nucleoli. | |||
**Centrocytes (mid germinal center). | **Centrocytes (mid germinal center). | ||
** | ***Cells with cleavage. | ||
**Centrocytes (transforming to immunoblasts) - usually deeper aspect. | |||
***Cells with cleavage. | |||
*''Tingible body macrophages'' - mid germinal center. | *''Tingible body macrophages'' - mid germinal center. | ||
*''Follicular dendritic cells''. | *''Follicular dendritic cells''. |
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