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Difference between revisions of "Pancreas"
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→See also: +acinar cell carcinoma of the pancreas
(→Pancreas neoplasms in a table: wikify) |
(→See also: +acinar cell carcinoma of the pancreas) |
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*[http://path.upmc.edu/cases/case172/micro.html Islet cell tumour (upmc.edu)]. | *[http://path.upmc.edu/cases/case172/micro.html Islet cell tumour (upmc.edu)]. | ||
*[http://path.upmc.edu/cases/case339.html Pancreatic NET with features of SPT (upmc.edu)]. | *[http://path.upmc.edu/cases/case339.html Pancreatic NET with features of SPT (upmc.edu)]. | ||
==Acinar cell carcinoma of the pancreas== | |||
:'''Not''' to be confused with ''[[acinic cell carcinoma]]''. | |||
*[[AKA]] ''acinar cell carcinoma''. | |||
===General=== | |||
*Rare. | |||
*Solid epithelial exocrine tumour.<ref>URL: [http://brighamrad.harvard.edu/Cases/bwh/hcache/380/full.html http://brighamrad.harvard.edu/Cases/bwh/hcache/380/full.html]. Accessed on: 15 January 2012.</ref> | |||
*Poor prognosis; mean survival of 18 months in one series.<ref name=pmid1384374/> | |||
Clinical:<ref name=pmid1384374>{{Cite journal | last1 = Klimstra | first1 = DS. | last2 = Heffess | first2 = CS. | last3 = Oertel | first3 = JE. | last4 = Rosai | first4 = J. | title = Acinar cell carcinoma of the pancreas. A clinicopathologic study of 28 cases. | journal = Am J Surg Pathol | volume = 16 | issue = 9 | pages = 815-37 | month = Sep | year = 1992 | doi = | PMID = 1384374 }}</ref> | |||
*Increased serum lipase. | |||
**May be associated with arthralgias (joint pain). | |||
===Gross=== | |||
*Usually head of pancreas. | |||
===Microscopic=== | |||
Features:<ref name=pmid1384374/> | |||
*Cells reminiscent of pancreatic acinus cells: | |||
**Granular, basophilic cytoplasm - usu. abundant. | |||
**Round/oval nucleus. | |||
***Nucleolus prominent. | |||
*Architecture: | |||
**Nests, sheets, trabecular, glandular. | |||
DDx: | |||
*[[Pancreatic neuroendocrine tumour]]. | |||
*[[Invasive ductal carcinoma of the pancreas]]. | |||
Images: | |||
*[http://path.upmc.edu/cases/case377.html Acinar cell carcinoma - several images (upmc.edu)]. | |||
*[http://brighamrad.harvard.edu/Cases/bwh/hcache/380/full.html Acinar cell carcinoma - several images (harvard.edu)]. | |||
===Stains=== | |||
Features:<ref name=pmid1384374/> | |||
*PAS +ve (granular). | |||
*PASD +ve. | |||
===IHC=== | |||
*Trypsin +ve -- '''key stain'''. | |||
*Chromogranin +ve (scattered, focal). | |||
*CD56 -ve. (?) | |||
=See also= | =See also= | ||