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Difference between revisions of "Colorectal tumours"
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+colorectal adenocarcinoma
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(+colorectal adenocarcinoma) |
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An introduction to gastrointestinal pathology is in the ''[[gastrointestinal pathology]]'' article. The precursor lesion of colorectal carcinoma (CRC) is, typically, an [[adenomatous polyps|adenomatous polyp]]. Polyps are discussed in the ''[[intestinal polyps]]'' article. | An introduction to gastrointestinal pathology is in the ''[[gastrointestinal pathology]]'' article. The precursor lesion of colorectal carcinoma (CRC) is, typically, an [[adenomatous polyps|adenomatous polyp]]. Polyps are discussed in the ''[[intestinal polyps]]'' article. | ||
=Classification= | |||
===Most common=== | ===Most common=== | ||
*Colon & rectum - most common = [[adenocarcinoma]].<ref name=Ref_PBoD864>{{Ref PBoD|864}}</ref> | *Colon & rectum - most common = [[adenocarcinoma]].<ref name=Ref_PBoD864>{{Ref PBoD|864}}</ref> | ||
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**Medullary.<ref name=pmid18283560>{{cite journal |author=Truta B, Chen YY, Blanco AM, ''et al.'' |title=Tumor histology helps to identify Lynch syndrome among colorectal cancer patients |journal=Fam. Cancer |volume=7 |issue=3 |pages=267–74 |year=2008 |pmid=18283560 |doi=10.1007/s10689-008-9186-8 |url=}}</ref> | **Medullary.<ref name=pmid18283560>{{cite journal |author=Truta B, Chen YY, Blanco AM, ''et al.'' |title=Tumor histology helps to identify Lynch syndrome among colorectal cancer patients |journal=Fam. Cancer |volume=7 |issue=3 |pages=267–74 |year=2008 |pmid=18283560 |doi=10.1007/s10689-008-9186-8 |url=}}</ref> | ||
==See also | =Specific entities= | ||
==Colorectal adenocarcinoma== | |||
*[[AKA]] ''adenocarcinoma''. | |||
===General=== | |||
*Very common. | |||
*Rectum and sigmoid > proximal large bowel. | |||
Presentation: | |||
*Bright red blood per rectum (BRBPR). | |||
*Constipation. | |||
*Symptoms of bowel obstruction - nausea, vomiting. | |||
===Gross=== | |||
Often circumferential or near circumferential: | |||
*These are referred to as "apple core lesion" ''or'' "napkin-ring" lesion. | |||
Mucosa: | |||
*Granular appearance. | |||
*Raised (exophytic) ''or'' heaped edges with ulceration. | |||
===Microscopic=== | |||
Features: | |||
*Nuclear atypia: | |||
**Nuclear pseudostratification. | |||
**Nuclear hyperchromasia. | |||
**Chromatin clearing or granularity. | |||
*+/-Necrosis. | |||
*Architecture: | |||
**Glands = well-differentiated. | |||
**Sheets = poorly-differentiated. | |||
===IHC=== | |||
*CK7 -ve. | |||
*CK20 +ve. | |||
*CEA +ve. | |||
*CDX2 +ve. | |||
=See also= | |||
*[[Anus]] - covers anal cancer and anal intraepithelial neoplasia. | *[[Anus]] - covers anal cancer and anal intraepithelial neoplasia. | ||
*[[Colon]]. | *[[Colon]]. | ||
*[[Gastrointestinal pathology]]. | *[[Gastrointestinal pathology]]. | ||
=References= | |||
{{reflist|2}} | {{reflist|2}} | ||
[[Category:Gastrointestinal pathology]] | [[Category:Gastrointestinal pathology]] | ||