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Difference between revisions of "Endometrial carcinoma"
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→Endometrioid endometrial carcinoma
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==Endometrioid endometrial carcinoma== | ==Endometrioid endometrial carcinoma== | ||
*[[AKA]] ''endometrioid endometrial adenocarcinoma''. | *[[AKA]] ''endometrioid endometrial adenocarcinoma''. | ||
===General=== | ===General=== | ||
*Good prognosis - usually. | *Good prognosis - usually. | ||
*Women in 40s & 50s. | *Women in 40s & 50s. | ||
* | *Associated with estrogen excess. | ||
**Typical patient is obese. | **Typical patient is obese. | ||
===Microscopic=== | ===Microscopic=== | ||
Features - | Features - one of the following four:<ref name=Ref_GP239>{{Ref GP|239}}</ref><ref name=pmid7074572>{{Cite journal | last1 = Kurman | first1 = RJ. | last2 = Norris | first2 = HJ. | title = Evaluation of criteria for distinguishing atypical endometrial hyperplasia from well-differentiated carcinoma. | journal = Cancer | volume = 49 | issue = 12 | pages = 2547-59 | month = Jun | year = 1982 | doi = | PMID = 7074572 }}</ref><ref>URL: [http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/Endometrium_11protocol.pdf http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/Endometrium_11protocol.pdf]. Accessed on: 12 January 2012.</ref> | ||
#Desmoplastic stromal response. | |||
#Confluent cribriform growth. † | |||
*Squamous metaplasia. | #Extensive papillary growth. † | ||
#Severe cytologic atypia. † | |||
*Squamous metaplasia - very common. | |||
**Look for ''squamous morules'': | **Look for ''squamous morules'': | ||
***Ball of cells with an intensely eosinophilic cytoplasm - '''key feature'''. | ***Ball of cells with an intensely eosinophilic cytoplasm - '''key feature'''. | ||
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***+/-Dyskeratotic cells. | ***+/-Dyskeratotic cells. | ||
Note: | |||
* † There is a size cut-off for criteria 2, 3 and 4: > 2.1 mm.<ref name=pmid7074572/> | |||
*Dyskeratosis = abnormal keratinization;<ref>URL: [http://dictionary.reference.com/browse/dyskeratosis http://dictionary.reference.com/browse/dyskeratosis]. Accessed on: 5 September 2011.</ref> classically have intensely eosinophilic cytoplasm +/- nuclear fragmentation ([http://dictionary.reference.com/browse/karyolysis?db=medical&q=karyolysis karyorrhexis]) - see: [http://www.drmihm.com/pictures/Figure%203.jpg several dyskeratotic cells]. | *Dyskeratosis = abnormal keratinization;<ref>URL: [http://dictionary.reference.com/browse/dyskeratosis http://dictionary.reference.com/browse/dyskeratosis]. Accessed on: 5 September 2011.</ref> classically have intensely eosinophilic cytoplasm +/- nuclear fragmentation ([http://dictionary.reference.com/browse/karyolysis?db=medical&q=karyolysis karyorrhexis]) - see: [http://www.drmihm.com/pictures/Figure%203.jpg several dyskeratotic cells]. | ||
*Squamous morules in endometrioid endometrial carcinoma - not | *Squamous morules in endometrioid endometrial carcinoma - not associated with [[HPV]] infection.<ref name=pmid15333650>{{Cite journal | last1 = Chinen | first1 = K. | last2 = Kamiyama | first2 = K. | last3 = Kinjo | first3 = T. | last4 = Arasaki | first4 = A. | last5 = Ihama | first5 = Y. | last6 = Hamada | first6 = T. | last7 = Iwamasa | first7 = T. | title = Morules in endometrial carcinoma and benign endometrial lesions differ from squamous differentiation tissue and are not infected with human papillomavirus. | journal = J Clin Pathol | volume = 57 | issue = 9 | pages = 918-26 | month = Sep | year = 2004 | doi = 10.1136/jcp.2004.017996 | PMID = 15333650 }}</ref> | ||
Image: | Image: | ||