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Difference between revisions of "Neuromuscular pathology"
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→Type 2 fibre atrophy: more
(→Nerve stuff: +drug) |
(→Type 2 fibre atrophy: more) |
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==Type 2 fibre atrophy== | ==Type 2 fibre atrophy== | ||
===General=== | |||
DDx: | DDx: | ||
*Disuse. | *Disuse. | ||
| Line 484: | Line 485: | ||
*Steroids. | *Steroids. | ||
*Others. | *Others. | ||
===Microscopic=== | |||
Features: | |||
*Atrophy for type 2 atrophy. | |||
Images: | Images: | ||
*[http://commons.wikimedia.org/wiki/File:Denervation_atrophy_-_high_mag.jpg Denervation atrophy - high mag. (WC)]. | *[http://commons.wikimedia.org/wiki/File:Denervation_atrophy_-_high_mag.jpg Denervation atrophy - high mag. (WC)]. | ||
*[http://commons.wikimedia.org/wiki/File:Denervation_atrophy_-_atp94_-_high_mag.jpg Type 2 fibre atrophy - ATPase pH 9.4 - high mag. (WC)]. | *[http://commons.wikimedia.org/wiki/File:Denervation_atrophy_-_atp94_-_high_mag.jpg Type 2 fibre atrophy - ATPase pH 9.4 - high mag. (WC)]. | ||
==Drug-induced rhabdomyolysis== | |||
*AKA ''drug-induced acute necrotizing myopathy''. | |||
===General=== | |||
Clinical:<ref name=pmid15021204>{{Cite journal | last1 = Coco | first1 = TJ. | last2 = Klasner | first2 = AE. | title = Drug-induced rhabdomyolysis. | journal = Curr Opin Pediatr | volume = 16 | issue = 2 | pages = 206-10 | month = Apr | year = 2004 | doi = | PMID = 15021204 }}</ref> | |||
*Myalgias. | |||
*Myoglobinuria. | |||
*Increased elevated serum creatine kinase. | |||
Causes: | |||
*Ecstasy (MDMA). | |||
*Statins. | |||
===Microscopic=== | |||
Features: | |||
*Muscle [[necrosis]]. | |||
** | |||
*No inflammation. | |||
*No perifascicular atrophy. | |||
Images: | |||
*[http://path.upmc.edu/cases/case184/micro.html Drug-induced rhabdomyolysis - several images (upmc.edu)]. | |||
==Nerve stuff== | ==Nerve stuff== | ||