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Difference between revisions of "Leukemia"
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(→Acute myeloid leukemia: +abbrev.) |
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**Classic presentation: non-tender lymph nodes | **Classic presentation: non-tender lymph nodes | ||
=Definition= | |||
All of the following:<ref name=dg21mar20011>D. Good. 21 March 2011.</ref> | All of the following:<ref name=dg21mar20011>D. Good. 21 March 2011.</ref> | ||
#Morphologic abnormalities. | #Morphologic abnormalities. | ||
| Line 19: | Line 19: | ||
*t(15;17). | *t(15;17). | ||
=Histomorphologic overview= | |||
{| class="wikitable" | {| class="wikitable" | ||
| '''Disease/Feature''' | | '''Disease/Feature''' | ||
| Line 26: | Line 26: | ||
| '''Granulation of cytoplasm''' | | '''Granulation of cytoplasm''' | ||
|- | |- | ||
| AML | | Acute myeloid leukemia (AML) | ||
| larger | | larger | ||
| present | | present | ||
| present | | present | ||
|- | |- | ||
| ALL | | Acute lymphoid leukemia (ALL) | ||
| smaller | | smaller † | ||
| none | | none | ||
| absent or present | | absent or present | ||
|} | |} | ||
† should be easy to remember as smALL people, i.e. kids, get this type of acute leukemia. | |||
==Clinical factors | |||
=Algorithms= | |||
There is a nice set of algorithms from D. Arber - that were presented at the 2009 USCAP. | |||
=Clinical factors in classification= | |||
Clinical are important in the classification of leukemia. | Clinical are important in the classification of leukemia. | ||
*Hx of [[myelodysplastic syndrome]]? | *Hx of [[myelodysplastic syndrome]]? | ||
| Line 43: | Line 48: | ||
*[[Down syndrome]]? | *[[Down syndrome]]? | ||
=Leukemia classification= | |||
Acute myeloid leukemia (AML): | Acute myeloid leukemia (AML): | ||
#AML. | #AML. | ||
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#T cell. | #T cell. | ||
===Acute myeloid leukemia | =Specific diagnoses= | ||
==Acute myeloid leukemia== | |||
*Abbreviated ''[[AML]]''. | *Abbreviated ''[[AML]]''. | ||
===General=== | |||
*Adults. | *Adults. | ||
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*[[Down syndrome]]. | *[[Down syndrome]]. | ||
===Microscopic=== | |||
Features: | Features: | ||
*Auer rods present | *Auer rods present | ||
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*[http://commons.wikimedia.org/wiki/File:Auer_rods.PNG Auer rods in an AML (WC)]. | *[http://commons.wikimedia.org/wiki/File:Auer_rods.PNG Auer rods in an AML (WC)]. | ||
===Molecular=== | |||
*Must exclude all the recurrent cytogenetic abnormalities - see below. | *Must exclude all the recurrent cytogenetic abnormalities - see below. | ||
==AML with recurrent cytogenetic abnormalities== | |||
===Acute myeloid leukemia with t(8;21)=== | |||
*t(8;21)(q22;q22).<ref>{{Cite journal | last1 = Berger | first1 = R. | title = Translocation t(8;21)(q22;q22): cytogenetics and molecular biology. | journal = Nouv Rev Fr Hematol | volume = 36 Suppl 1 | issue = | pages = S67-9 | month = | year = 1994 | doi = | PMID = 8177719 }}</ref> | *t(8;21)(q22;q22).<ref>{{Cite journal | last1 = Berger | first1 = R. | title = Translocation t(8;21)(q22;q22): cytogenetics and molecular biology. | journal = Nouv Rev Fr Hematol | volume = 36 Suppl 1 | issue = | pages = S67-9 | month = | year = 1994 | doi = | PMID = 8177719 }}</ref> | ||
| Line 91: | Line 94: | ||
*CD19+, PAX5+, CD79a +/-. | *CD19+, PAX5+, CD79a +/-. | ||
===Acute myeloid leukemia with inv(16)=== | |||
*inv(16)(p13.1q22).<ref name=pmid16917916>{{Cite journal | last1 = Lu | first1 = CM. | last2 = Murata-Collins | first2 = JL. | last3 = Wang | first3 = E. | last4 = Siddiqi | first4 = I. | last5 = Lawrence | first5 = HJ. | title = Concurrent acute myeloid leukemia with inv(16)(p13.1q22) and chronic lymphocytic leukemia: molecular evidence of two separate diseases. | journal = Am J Hematol | volume = 81 | issue = 12 | pages = 963-8 | month = Dec | year = 2006 | doi = 10.1002/ajh.20716 | PMID = 16917916 }} | *inv(16)(p13.1q22).<ref name=pmid16917916>{{Cite journal | last1 = Lu | first1 = CM. | last2 = Murata-Collins | first2 = JL. | last3 = Wang | first3 = E. | last4 = Siddiqi | first4 = I. | last5 = Lawrence | first5 = HJ. | title = Concurrent acute myeloid leukemia with inv(16)(p13.1q22) and chronic lymphocytic leukemia: molecular evidence of two separate diseases. | journal = Am J Hematol | volume = 81 | issue = 12 | pages = 963-8 | month = Dec | year = 2006 | doi = 10.1002/ajh.20716 | PMID = 16917916 }} | ||
</ref> | </ref> | ||
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*CD2+ -- common. | *CD2+ -- common. | ||
===Acute myeloid leukemia with t(15;17)=== | |||
*t(15;17)(q22;q12). | *t(15;17)(q22;q12). | ||
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*t(5;17). (???) | *t(5;17). (???) | ||
===Acute myeloid leukemia with t(9;11)=== | |||
*t(9;11). | *t(9;11). | ||
| Line 150: | Line 153: | ||
*CD13+. (???) | *CD13+. (???) | ||
=See also= | |||
*[[Lymphoma]]. | *[[Lymphoma]]. | ||
*[[Myelodysplastic syndromes]] | *[[Myelodysplastic syndromes]] | ||
=References= | |||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Haematopathology]] | [[Category:Haematopathology]] | ||