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Difference between revisions of "Malignant melanoma"
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===Skin=== | ===Skin=== | ||
Features (skin): | Features (skin): | ||
#Melanocytic differentiation: | |||
#*Pigmentation (melanin). | |||
#*Nuclear pseudoinclusion. | |||
#*Gray cytoplasm. | |||
#*Clear (artefactual) halo around cells. | |||
#Architecture: | #Architecture: | ||
#*Sheeting - diagnostic. | #*Sheeting - '''diagnostic'''. | ||
#*Asymmetry. | #*Asymmetry - as judged from low power magnification. | ||
#Lack of maturation - see below. | #Lack of maturation - see below. | ||
#+/-[[Nuclear atypia]]. | #+/-[[Nuclear atypia]] - esp. nucleoli. | ||
#*May be seen in a [[Spitz nevus]]. | #*May be seen in a [[Spitz nevus]]. | ||
#+/-Upward scatter of melanocytes [[AKA]] intraepidermal ascent - "cannonball" appearance. | #+/-Upward scatter of melanocytes [[AKA]] intraepidermal ascent - "cannonball" appearance. | ||