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Difference between revisions of "Immunohistochemical staining"
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→Germ cell tumours
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==Germ cell tumours== | ==Germ cell tumours== | ||
===Seminoma=== | ===Seminoma=== | ||
*D2-40.<ref name=pmid18045648/> | *D2-40 +ve.<ref name=pmid18045648/> | ||
*OCT 3/4 +ve. | |||
===Embryonal carcinoma=== | ===Embryonal carcinoma=== | ||
*CD30+ - cytoplasm, cell membrane, Golgi. | *CD30 +ve - cytoplasm, cell membrane, Golgi. | ||
** | **Rarely positive in seminoma. | ||
*CK7 +ve.<ref name=pmid10761461>{{cite journal |author=Cheville JC, Rao S, Iczkowski KA, Lohse CM, Pankratz VS |title=Cytokeratin expression in seminoma of the human testis |journal=Am. J. Clin. Pathol. |volume=113 |issue=4 |pages=583–8 |year=2000 |month=April |pmid=10761461 |doi=10.1309/3QLC-5MF1-JYXU-A5XX |url=}}</ref> | |||
*AE1/AE3 +ve. | |||
===Yolk sac tumour (endodermal sinus tumour)=== | ===Yolk sac tumour (endodermal sinus tumour)=== | ||
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*beta-hCG. | *beta-hCG. | ||
=== | ===Bare bones mnemonic for GCTs=== | ||
The germ cell tumour (GCT) IHC mnemonic ''ABCD'': | The germ cell tumour (GCT) IHC mnemonic ''ABCD'': | ||
*AFP = yolk sac tumour. | *AFP = yolk sac tumour. | ||