48,835
edits
(→Aristolochic acid nephropathy: +fibrillary glomerulonephritis) |
|||
Line 1,000: | Line 1,000: | ||
===Light chain deposition=== | ===Light chain deposition=== | ||
*Usually associated with kappa clone. | *Usually associated with kappa clone. | ||
==Fibrillary glomerulonephritis== | |||
*[[AKA]] ''Fibrillary glomerulopathy''. | |||
===General=== | |||
*Rare ~ 1% native kidney biopsies.<ref name=pmid18045849>{{Cite journal | last1 = Alpers | first1 = CE. | last2 = Kowalewska | first2 = J. | title = Fibrillary glomerulonephritis and immunotactoid glomerulopathy. | journal = J Am Soc Nephrol | volume = 19 | issue = 1 | pages = 34-7 | month = Jan | year = 2008 | doi = 10.1681/ASN.2007070757 | PMID = 18045849 | URL = http://jasn.asnjournals.org/content/19/1/34.long }} | |||
</ref> | |||
*Presents as [[nephrotic syndrome]]. | |||
*Prognosis poor; large number progress to ESRD. | |||
===Microscopic=== | |||
Features: | |||
*Mesangial matrix expansion. | |||
*Thickened capillary walls. | |||
Images: | |||
*[http://jasn.asnjournals.org/content/19/1/34/F1.expansion.html FG (asnjournals.org)].<ref name=pmid18045849/> | |||
===IF=== | |||
*IgG predominant.<ref name=pmid18045849/> | |||
===Stains=== | |||
*[[Congo red stain]] -ve. | |||
===EM=== | |||
*Fibrils:<ref name=pmid18045849/> | |||
**Non-branching. | |||
**Randomly arranged. | |||
**Usu. 18-20 nm in diameter -- larger than amyloid (see below). | |||
***Size range 12-24 nm. | |||
Note: | |||
*Amyloid: between 8 and 15 nm, most often 8-12 nm.<ref name=pmid18045849/> | |||
==Aristolochic acid nephropathy== | ==Aristolochic acid nephropathy== |
edits