Difference between revisions of "Medical kidney diseases"

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1,154 bytes added ,  22:49, 2 January 2012
→‎Aristolochic acid nephropathy: +fibrillary glomerulonephritis
(→‎Aristolochic acid nephropathy: +fibrillary glomerulonephritis)
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===Light chain deposition===
===Light chain deposition===
*Usually associated with kappa clone.
*Usually associated with kappa clone.
==Fibrillary glomerulonephritis==
*[[AKA]] ''Fibrillary glomerulopathy''.
===General===
*Rare ~ 1% native kidney biopsies.<ref name=pmid18045849>{{Cite journal  | last1 = Alpers | first1 = CE. | last2 = Kowalewska | first2 = J. | title = Fibrillary glomerulonephritis and immunotactoid glomerulopathy. | journal = J Am Soc Nephrol | volume = 19 | issue = 1 | pages = 34-7 | month = Jan | year = 2008 | doi = 10.1681/ASN.2007070757 | PMID = 18045849 | URL = http://jasn.asnjournals.org/content/19/1/34.long }}
</ref>
*Presents as [[nephrotic syndrome]].
*Prognosis poor; large number progress to ESRD.
===Microscopic===
Features:
*Mesangial matrix expansion.
*Thickened capillary walls.
Images:
*[http://jasn.asnjournals.org/content/19/1/34/F1.expansion.html FG (asnjournals.org)].<ref name=pmid18045849/>
===IF===
*IgG predominant.<ref name=pmid18045849/>
===Stains===
*[[Congo red stain]] -ve.
===EM===
*Fibrils:<ref name=pmid18045849/>
**Non-branching.
**Randomly arranged.
**Usu. 18-20 nm in diameter -- larger than amyloid (see below).
***Size range 12-24 nm.
Note:
*Amyloid: between 8 and 15 nm, most often 8-12 nm.<ref name=pmid18045849/>


==Aristolochic acid nephropathy==
==Aristolochic acid nephropathy==
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