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Difference between revisions of "Vascular disease"
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→See also: +cholesterol embolus
m (→Thrombosis) |
(→See also: +cholesterol embolus) |
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Image: | Image: | ||
*[http://commons.wikimedia.org/wiki/File:Fetal_thrombotic_vasculopathy_-_high_mag.jpg Intravascular fibrin - high mag. (WC)]. | *[http://commons.wikimedia.org/wiki/File:Fetal_thrombotic_vasculopathy_-_high_mag.jpg Intravascular fibrin - high mag. (WC)]. | ||
==Cholesterol embolism== | |||
===General=== | |||
*Strong association with atherosclerosis - found in ~3% of individuals in an [[autopsy]] series of 267 older individuals (mean age ~65 years).<ref name=pmid19970827>{{cite journal | author=Flory CM | title=Arterial occlusions produced by emboli from eroded aortic atheromatous plaques | journal=Am J Pathol | year= 1945 | volume=21 | pages=549–565 | pmid=19970827 | issue=3 | pmc=1934118}} {{PMC|1934118}}</ref> | |||
===Microscopic=== | |||
Features:<ref name=Ref_Sternberg5_1735-6>{{Ref Sternberg5|1735-6}}</ref> | |||
*Intravascular cholesterol clefts (biconvex white spaces) - '''key feature'''. | |||
**Typically ~ 100-500 micrometers. | |||
*+/-Macrophages and giant cells. | |||
*+/-Eosinophils. | |||
Note: | |||
*May be associated with ischemic changes and necrosis. | |||
*Usually in the context of severe atherosclerosis. | |||
Note (trivia): | |||
*Cholesterol crystals dissolve with routine processing (paraffin embedding). | |||
Images: | |||
*[http://commons.wikimedia.org/wiki/File:Cholesterol_embolus_-_intermed_mag.jpg Cholesterol embolus - intermed. mag. (WC)]. | |||
*[http://commons.wikimedia.org/wiki/File:Cholesterol_embolus_-_high_mag.jpg Cholesterol embolus - high mag. (WC)]. | |||
==See also== | ==See also== | ||