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===Electron microscopy=== | ===Electron microscopy=== | ||
*Granular osmiophilic material (GOM). | *Granular osmiophilic material (GOM). | ||
==Binswanger's disease== | |||
===General=== | |||
*Multi-infarct dementia affecting subcortical white matter. | |||
*Waste-basket diagnosis; diagnosed if CADASIL and amyloidosis have been excluded. | |||
*Diagnosis has been controversial -- most with this entity (in the past) were diagnosed with ''Alzheimer's disease''. | |||
===Microscopic=== | |||
Features: | |||
*Subcortical lesions that replace the myelin consisting of macrophages. | |||
==See also== | ==See also== |
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