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Difference between revisions of "Uterine tumours"
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→Microscopic
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===Microscopic=== | ===Microscopic=== | ||
Features: | Features: | ||
*Smooth muscle differentiation | *Smooth muscle differentiation - '''key feature'''. | ||
**Fascicular architecture. | **Fascicular architecture. | ||
**May rely on IHC - if poorly differentiated. | **May rely on [[IHC]] - if poorly differentiated. | ||
#Cellular atypia - common. | *Malignant histomorphologic features - all three required: | ||
#[[Necrosis]]. | *#Cellular atypia - common. | ||
#*Should be patchy/multifocal. | *#[[Necrosis]]. | ||
#*Zonal necrosis is suggestive of vascular cause. | *#*Should be patchy/multifocal. | ||
#Mitoses - '''key feature'''. | *#*Zonal necrosis is suggestive of vascular cause. | ||
#*10 mitoses/HPF. | *#Mitoses - '''key feature'''. | ||
#*5 mitoses/HPF - if epithelioid. | *#*10 mitoses/HPF. | ||
#*2 mitoses/HPF - if myxoid. | *#*5 mitoses/HPF - if epithelioid. | ||
*#*2 mitoses/HPF - if myxoid. | |||
===IHC=== | ===IHC=== | ||