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Difference between revisions of "Liver neoplasms"
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→Fibrolamellar HCC: more
m (→IHC) |
(→Fibrolamellar HCC: more) |
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====Fibrolamellar HCC==== | ====Fibrolamellar HCC==== | ||
=====General===== | |||
*Rare variant. | |||
*Classifically afflicits younger patients. | |||
**Mean age at onset ~27 years in one study.<ref name=pmid16475212>{{Cite journal | last1 = Stipa | first1 = F. | last2 = Yoon | first2 = SS. | last3 = Liau | first3 = KH. | last4 = Fong | first4 = Y. | last5 = Jarnagin | first5 = WR. | last6 = D'Angelica | first6 = M. | last7 = Abou-Alfa | first7 = G. | last8 = Blumgart | first8 = LH. | last9 = DeMatteo | first9 = RP. | title = Outcome of patients with fibrolamellar hepatocellular carcinoma. | journal = Cancer | volume = 106 | issue = 6 | pages = 1331-8 | month = Mar | year = 2006 | doi = 10.1002/cncr.21703 | PMID = 16475212 }}</ref> | |||
*Individuals usu. don't have the classic risk factors for HCC, i.e. no [[cirrhosis]], no hepatitis.<ref name=pmid16475212/> | |||
Clinical: | |||
*AFP usu. not elevated.<ref name=pmid16475212/> | |||
=====Microscopic===== | |||
Features:<ref>{{Ref GLP|595-6}}</ref> | Features:<ref>{{Ref GLP|595-6}}</ref> | ||
*Large polygonal tumours cells with: | *Large polygonal tumours cells with: | ||