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Difference between revisions of "Neuropathology"
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→Central pontine myelinolysis
(→Vascular malformations: +CPM) |
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==Central pontine myelinolysis== | ==Central pontine myelinolysis== | ||
===General=== | ===General=== | ||
*Classically in the pons, ergo "pontine" in the name. | *Classically in the pons, ergo "pontine" in the name. | ||
**May occur elsewhere -- known as ''extrapontine myelinolysis''. | **May occur elsewhere -- known as ''extrapontine myelinolysis''. | ||
| Line 584: | Line 583: | ||
*Rapid correction of hyponatremia.<ref name=pmid22080394>{{Cite journal | last1 = Chang | first1 = Y. | last2 = An | first2 = DH. | last3 = Xing | first3 = Y. | last4 = Qi | first4 = X. | title = Central pontine and extrapontine myelinolysis associated with acute hepatic dysfunction. | journal = Neurol Sci | volume = | issue = | pages = | month = Nov | year = 2011 | doi = 10.1007/s10072-011-0838-3 | PMID = 22080394 }}</ref> | *Rapid correction of hyponatremia.<ref name=pmid22080394>{{Cite journal | last1 = Chang | first1 = Y. | last2 = An | first2 = DH. | last3 = Xing | first3 = Y. | last4 = Qi | first4 = X. | title = Central pontine and extrapontine myelinolysis associated with acute hepatic dysfunction. | journal = Neurol Sci | volume = | issue = | pages = | month = Nov | year = 2011 | doi = 10.1007/s10072-011-0838-3 | PMID = 22080394 }}</ref> | ||
*Tacrolimus post-liver transplant.<ref name=pmid21959523>{{Cite journal | last1 = Fukazawa | first1 = K. | last2 = Nishida | first2 = S. | last3 = Aguina | first3 = L. | last4 = Pretto | first4 = E. | title = Central pontine myelinolysis (CPM) associated with tacrolimus (FK506) after liver transplantation. | journal = Ann Transplant | volume = 16 | issue = 3 | pages = 139-42 | month = Sep | year = 2011 | doi = | PMID = 21959523 }}</ref> | *Tacrolimus post-liver transplant.<ref name=pmid21959523>{{Cite journal | last1 = Fukazawa | first1 = K. | last2 = Nishida | first2 = S. | last3 = Aguina | first3 = L. | last4 = Pretto | first4 = E. | title = Central pontine myelinolysis (CPM) associated with tacrolimus (FK506) after liver transplantation. | journal = Ann Transplant | volume = 16 | issue = 3 | pages = 139-42 | month = Sep | year = 2011 | doi = | PMID = 21959523 }}</ref> | ||
*Associated with alcoholism and malnourishment. | |||
Clinical:<ref>{{Cite journal | last1 = Lai | first1 = CC. | last2 = Tan | first2 = CK. | last3 = Lin | first3 = SH. | last4 = Chen | first4 = HW. | title = Central pontine myelinolysis. | journal = CMAJ | volume = 183 | issue = 9 | pages = E605 | month = Jun | year = 2011 | doi = 10.1503/cmaj.090186 | PMID = 21543311 | PMC = 3114939 | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114939/?tool=pubmed }}</ref> | Clinical:<ref>{{Cite journal | last1 = Lai | first1 = CC. | last2 = Tan | first2 = CK. | last3 = Lin | first3 = SH. | last4 = Chen | first4 = HW. | title = Central pontine myelinolysis. | journal = CMAJ | volume = 183 | issue = 9 | pages = E605 | month = Jun | year = 2011 | doi = 10.1503/cmaj.090186 | PMID = 21543311 | PMC = 3114939 | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114939/?tool=pubmed }}</ref> | ||
*Decreased level of consciousness - most common. | *Decreased level of consciousness - most common. | ||
*Quadriplegia. | *Quadriplegia. | ||
*Poor prognosis. | |||
===Microscopic=== | ===Microscopic=== | ||